Results 1 to 10 of about 4,532 (131)

Mathematical Model Predicting the Kinetics of Intracellular LCMV Replication

Mathematics, 2023
The lymphocytic choriomeningitis virus (LCMV) is a non-cytopathic virus broadly used in fundamental immunology as a mouse model for acute and chronic virus infections.
Valentina Casella, Gennady Bocharov, Dmitry Grebennikov   +2 more
exaly   +4 more sources

Replication-incompetent rabies virus vector harboring glycoprotein gene of lymphocytic choriomeningitis virus (LCMV) protects mice from LCMV challenge. [PDF]

PLoS Neglected Tropical Diseases, 2018
BACKGROUND:Lymphocytic choriomeningitis virus (LCMV) causes a variety of diseases, including asymptomatic infections, meningitis, and congenital infections in the fetus of infected mother.
Mutsuyo Takayama-Ito, Chang-Kweng Lim, Yukie Yamaguchi, Guillermo Posadas-Herrera, Hirofumi Kato, Itoe Iizuka, Md Taimur Islam, Kinjiro Morimoto, Masayuki Saijo   +8 more
doaj   +2 more sources

Identification of potential novel hosts and the risk of infection with lymphocytic choriomeningitis virus in humans in Gabon, Central Africa

International Journal of Infectious Diseases, 2021
Objectives: Lymphocytic choriomeningitis virus (LCMV), a human pathogenic arenavirus, is distributed worldwide. However, no human cases have been reported in Africa.
Yuri Ushijima, Haruka Abe, Takehiro Ozeki, Georgelin N. Ondo, Marien J.V.M. Mbadinga, Rodrigue Bikangui, Chimène Nze-Nkogue, Etienne F. Akomo-Okoue, Ghislain W.E. Ella, Lilian B.M. Koumba, Branly C.B.B. Nso, Rodrigue Mintsa-Nguema, Patrice Makouloutou-Nzassi, Boris K. Makanga, Fred L.M. Nguelet, Vahid R. Zadeh, Shuzo Urata, Armel V.N. Mbouna, Marguerite Massinga-Loembe, Selidji T. Agnandji, Bertrand Lell, Jiro Yasuda   +21 more
doaj   +1 more source

PDIA4 Is a Host Factor Important for Lymphocytic Choriomeningitis Virus Infection

Viruses, 2023
Mammalian arenaviruses are rodent-borne zoonotic viruses, some of which can cause fatal hemorrhagic diseases in humans. The first discovered arenavirus, lymphocytic choriomeningitis virus (LCMV), has a worldwide distribution and can be fatal for ...
Mengwei Xu, Huan Xu, Weiwei Wan, Xiaoqin Jian, Runming Jin, Lin Wang, Jingshi Wang, Gengfu Xiao, Leike Zhang, Hongbo Chen, Yuxi Wen   +10 more
doaj   +1 more source

Armstrong strain lymphocytic choriomeningitis virus infection after accidental laboratory exposure

Virology Journal, 2023
Background Lymphocytic choriomeningitis virus (LCMV) is a human pathogen naturally present in wild rodents. In addition, LCMV is routinely used in immunology research as a model of viral infection in mice.
Laurence Caron, Jean-Sébastien Delisle, James E Strong, Yvon Deschambault, Félix Lombard-Vadnais, Annie-Claude Labbé, Sylvie Lesage   +6 more
doaj   +1 more source

Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection

Virulence, 2020
Leukocyte function-associated antigen 1 (LFA-1) is the most widely expressed member of the β2 integrin family of cell-cell adhesion molecules. Although LFA-1 is thought to regulate multiple aspects of T cell immunity, its role in the response of CD8+ T ...
Mario Perro, Matteo Iannacone, Ulrich H. von Andrian, Antonio Peixoto   +3 more
doaj   +1 more source

Lymphocytic Choriomeningitis Virus Infections and Seroprevalence, Southern Iraq

Emerging Infectious Diseases, 2020
Acute febrile neurological infection cases in southern Iraq (N = 212) were screened for lymphocytic choriomeningitis virus (LCMV). Two LCMV IgM–positive serum samples and 2 cerebrospinal fluid samples with phylogenetically distinct LCMV strains were ...
Hussein Alburkat, Anne J. Jääskeläinen, Ali M. Barakat, Hassan J. Hasony, Tarja Sironen, Haider Al-hello, Teemu Smura, Olli Vapalahti   +7 more
doaj   +1 more source

New Perspective on the Geographic Distribution and Evolution of Lymphocytic Choriomeningitis Virus, Central Europe

Emerging Infectious Diseases, 2021
Lymphocytic choriomeningitis virus (LCMV) is an Old World mammarenavirus found worldwide because of its association with the house mouse. When LCMV spills over to immunocompetent humans, the virus can cause aseptic meningitis; in immunocompromised ...
Alena Fornůsková, Zuzana Hiadlovská, Miloš Macholán, Jaroslav Piálek, Joëlle Goüy de Bellocq   +4 more
doaj   +1 more source

Clonal exhaustion as a mechanism to protect against severe immunopathology and death from an overwhelming CD8 T cell response.

Frontiers in Immunology, 2013
The balance between protective immunity and immunopathology often determines the fate of the virus-infected host. How rapidly virus is cleared is a function of initial viral load, viral replication rate, and efficiency of the immune response.
Markus eCornberg, Markus eCornberg, Laurie Lea Kenney, Alex T Chen, Sung-Kwon eKim, Hans Peter Dienes, Stephen eWaggoner, Raymond M Welsh, Liisa Kaarina Selin   +8 more
doaj   +1 more source

Congenitally acquired persistent lymphocytic choriomeningitis viral infection reduces neuronal progenitor pools in the adult hippocampus and subventricular zone. [PDF]

PLoS ONE, 2014
Lymphocytic choriomeningitis virus (LCMV) can be transmitted through congenital infection, leading to persistent infection of numerous organ systems including the central nervous system (CNS).
Tony Sun, Michael J Vasek, Robyn S Klein
doaj   +1 more source