Results 41 to 50 of about 4,532 (131)

Detection of infectious LCMV under experimental conditions with limited virus titers: comparison of 1-step and 2-step LCMV-NP FACS and plaque assays.

open access: yes, 2012
(A) For validation of the AF647-conjugated LCMV-NP antibody, serum titers of LCMV cl13 infected mice (d.p.i) were analyzed by LCMV-NP FACS using both conjugated and unconjugated versions of the antibody; viral titers are represented in “derived PFU/ml”. (
Dirk Homann (164006)   +1 more
core   +1 more source

Direct infection of dendritic cells during chronic viral infection suppresses antiviral T cell proliferation and induces IL-10 expression in CD4 T cells.

open access: yesPLoS ONE, 2014
Elevated levels of systemic IL-10 have been associated with several chronic viral infections, including HCV, EBV, HCMV and LCMV. In the chronic LCMV infection model, both elevated IL-10 and enhanced infection of dendritic cells (DCs) are important for ...
Carmen Baca Jones   +5 more
doaj   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

open access: yesImmunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu   +24 more
wiley   +1 more source

Neutralization of JAM-C has no significant influence on the frequency of LCMV-specific T cells.

open access: yes, 2013
- The presence of LCMV-specific CD8 T cells on day 7 (A) and 28 (B) after LCMV-infection in the spleen and PDLN of RIP-LCMV-NP mice treated with anti-JAM-C antibody or isotype-matched control antibody was analyzed by ICCS (IFN-γ) after o/n in vitro ...
Edith Hintermann (92939)   +10 more
core   +1 more source

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

open access: yesAdvanced Science, Volume 13, Issue 57, 14 October 2026.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang   +9 more
wiley   +1 more source

Clinical Scoring of LCMV infected mice.

open access: yes, 2016
Clinical Scoring of LCMV infected mice.
Dowty Movita (3330822)   +7 more
core   +1 more source

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

open access: yesAdvanced Science, Volume 13, Issue 57, 14 October 2026.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger   +8 more
wiley   +1 more source

Survival curves in mice inoculated with adenovirus vectors before LCMV-WE infection.

open access: yes, 2018
(A) The schedules of immunization with adenovirus and LCMV challenge in C57BL/6 mice. Mice were inoculated twice with Ax-LCMV/GPC or Ax-empty at 1-week intervals. One week after the last inoculation of adenovirus, mice were challenged with 10 PFU of LCMV-
Md. Taimur Islam (5104844)   +8 more
core   +1 more source

Live-attenuated lymphocytic choriomeningitis virus-based vaccines for active immunotherapy of HPV16-positive cancer

open access: yesOncoImmunology, 2020
Infection with human papillomavirus (HPV) is associated with a variety of cancer types and limited therapy options. Therapeutic cancer vaccines targeting the HPV16 oncoproteins E6 and E7 have recently been extensively explored as a promising ...
Sarah Schmidt   +17 more
doaj   +1 more source

Nicotinamide Metabolism Constrains Memory CD8+ T Cell Formation Through a Putative HS1BP3‐SIRT1‐FOXO3‐BCL6 Axis

open access: yesAdvanced Science, Volume 13, Issue 57, 14 October 2026.
ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐binding protein 3 (HS1BP3) is preferentially expressed in memory CD8+ T cells.
Siyang Wang   +13 more
wiley   +1 more source

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