Results 81 to 90 of about 6,793 (233)
3-dimensional patient-derived lung cancer assays reveal resistance to standards-of-care promoted by stromal cells but sensitivity to histone deacetylase inhibitors [PDF]
, 2016 There is a growing recognition that current preclinical models do not reflect the tumor microenvironment in cellular, biological, and biophysical content and this may have a profound effect on drug efficacy testing, especially in the era of molecular ...
Alexander M. Reece-Smith +18 more
core +2 more sources
In-depth molecular analysis of combined and co-primary pulmonary large cell neuroendocrine carcinoma and adenocarcinoma [PDF]
, 2022 Up to 14% of large cell neuroendocrine carcinomas (LCNECs) are diagnosed in continuity with nonsmall cell lung carcinoma. In addition to these combined lesions, 1% to 7% of lung tumors present as co-primary tumors with multiple synchronous lesions.
+15 more
core +2 more sources
Case Reports in Medicine, Volume 2026, Issue 1, 2026.A 47‐year‐old woman presented with significant respiratory symptoms and was diagnosed with a bronchial tumor. Histological analysis confirmed the tumor, initially treated with endobronchial treatment (EBT), was a typical carcinoid. Given the patient’s improved pulmonary function and in accordance with current clinical guidelines, she underwent video ...
Yangbo Qiu +4 more
wiley +1 more source
Advances of Treatment of Pulmonary Large Cell Neuroendocrine Carcinoma
Chinese Journal of Lung CancerLarge cell neuroendocrine carcinoma (LCNEC) of lung is a rare neuroendocrine carcinoma subtype with difficulty in early diagnosis and poor prognosis which is treated with standard strategies of small cell lung cancer and non-small cell lung cancer.
Jiayi SUN +4 more
doaj +1 more source
Molecular Oncology, Volume 19, Issue 12, Page 3806-3820, December 2025.Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf +10 more
wiley +1 more source
Efficacy of second-line chemotherapy in patients with pulmonary large cell neuroendocrine carcinoma
Scientific ReportsThe efficacy of second-line chemotherapy in patients with pulmonary large cell neuroendocrine carcinoma (LCNEC) is unclear. This study aimed to evaluate the efficacy of second-line chemotherapy in patients with pulmonary LCNEC.
Yuko Iida +17 more
doaj +1 more source
P66.08 Differential Expression of INSM1 Between Pure SCLC and LCNEC After Surgical Resection and Its Clinicopathological Significance [PDF]
, 2021 Yihan Cao +10 more
openalex +1 more source
The Epidemiology of Neuroendocrine Carcinomas in Taiwan: A Population‐Based Cancer Registry Study
Cancer Medicine, Volume 14, Issue 21, November 2025.Differences in the incidence trends and clinical outcomes of NECs suggest different etiologies and heterogeneities of NECs. Further investigations on risk factor identification and novel treatment strategies for NECs are warranted. ABSTRACT Background Lung and small cell neuroendocrine carcinomas (SCCs) are the most common sites and histological types ...
Yi‐Hsin Yang +5 more
wiley +1 more source
Frontiers in Genetics, 2023 Background: According to the 2015 World Health Organization classification, large cell neuroendocrine carcinoma (LCNEC) was isolated from Large-cell lung cancer (LCLC) tumors, which constitutes 2%–3% of non-small cell lung cancer (NSCLC).
Xiaowei Wu, Jin Yin, Yu Deng, Yukun Zu
doaj +1 more source