Results 61 to 70 of about 19,064,740 (336)

Seipin is required for converting nascent to mature lipid droplets

eLife, 2016
How proteins control the biogenesis of cellular lipid droplets (LDs) is poorly understood. Using Drosophila and human cells, we show here that seipin, an ER protein implicated in LD biology, mediates a discrete step in LD formation—the conversion of ...
Huajin Wang, Michel Becuwe, B. Housden, Chandramohan Chitraju, Ashley J. Porras, Morven M. Graham, Xinran Liu, A. Thiam, D. Savage, A. Agarwal, A. Garg, Maria-Jesus Olarte, Qingqing Lin, F. Fröhlich, H. Hannibal-Bach, S. Upadhyayula, N. Perrimon, T. Kirchhausen, Christer S. Ejsing, T. Walther, Robert V Farese   +20 more
semanticscholar   +1 more source

Sex-dependent influence of endogenous estrogen in pulmonary hypertension [PDF]

, 2014
Rationale: The incidence of pulmonary arterial hypertension (PAH) is greater in women suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in males exogenously administered estrogen can protect against PH; however in models ...
Audrey F. Wright, David J. Rowlands, Dukes M, Girerd B, Josephine Fullerton, Kirsty M. Mair, Lynn Loughlin, Margaret Nilsen, Margaret R. MacLean, Martin J. Hussey, Matthew Thomas, Muxfeldt ES, Nicholas Duggan, Popovic RM, Silber DH, Sonia Roberts, Takahashi H, Teichmann J   +17 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Genetic differences in transcript responses to low-dose ionizing radiation identify tissue functions associated with breast cancer susceptibility.

PLoS ONE, 2012
High dose ionizing radiation (IR) is a well-known risk factor for breast cancer but the health effects after low-dose (LD,
Antoine M Snijders, Francesco Marchetti, Sandhya Bhatnagar, Nadire Duru, Ju Han, Zhi Hu, Jian-Hua Mao, Joe W Gray, Andrew J Wyrobek   +8 more
doaj   +1 more source

Sustainable Approach for Linz-Donawitz Slag Waste as a Replacement of Cement in Concrete: Mechanical, Microstructural, and Durability Properties

Advances in Civil Engineering, 2020
Linz-Donawitz (LD) slag, solid waste produced during steel manufacture in basic oxygen furnace, is difficult when it comes to handling and disposal and has very limited utilization.
Richa Palod, S. V. Deo, G. D. Ramtekkar
doaj   +1 more source

Evidence for single top quark production at D0 [PDF]

, 2007
The results of the first analysis to show evidence for production of single top quarks are presented. Using 0.9 fb-1 of data collected with the D0 detector at the Fermilab Tevatron, the analysis is performed in the electron+jets and muon+jets decay modes,
Garcia-Bellido, Aran
core   +1 more source

Electron-based crystalline undulator

, 2007
We discuss the features of a crystalline undulator of the novel type based on the effect of a planar channeling of ultra-relativistic electrons in a periodically bent crystals.
, Adejshvili D I, Adejshvili D I, Adejshvili D I, Alferov D F, Andrei V Korol, Andrey V Solov'yov, Baier V N, Baier V N, Baranov V T, Baranov V T, Biruykov V M, Carrigan R A, Hubbel J H Seltzer S M, Kaplin V V, Korol A V, Korol A V, Korol A V, Korol A V, Korol A V, Korol A V, Krause W, Kumakhov M A, Kumakhov M A, Lindhard J, Mehdi Tabrizi, Rullhusen P, Tabrizi M, Walter Greiner, Yao W M   +29 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

A single center, pilot, double-blinded, randomized, comparative, prospective clinical study to evaluate improvements in the structure and function of facial skin with tazarotene 0.1% cream alone and in combination with GliSODin® Skin Nutrients Advanced A

Clinical, Cosmetic and Investigational Dermatology, 2014
Lawrence D Goldberg, Corina CryslerShaft Medical San Diego, San Diego, CA, USABackground: Superoxide dismutase (SOD) reduces the reactive oxygen species formation associated with oxidative stress.
Goldberg LD, Crysler C
doaj  

Psychosis and the control of lucid dreaming

Frontiers in Psychology, 2016
Dreaming and psychosis share important features, such as intrinsic senseperceptions independent of external stimulation, and a general lack of criticism that is associated with reduced frontal cerebral activity.
Natália Bezerra Mota, Adara eResende, Sérgio Arthuro Mota-Rolim, Sérgio Arthuro Mota-Rolim, Mauro eCopelli, Sidarta eRibeiro   +5 more
doaj   +1 more source