Results 1 to 10 of about 239,253 (141)

Targeting LDL Cholesterol With LNA

Molecular Therapy: Nucleic Acids, 2012
Cardiovascular disease is the number one cause of death in the industrialized world. Much of the morbidity and mortality from heart disease can be linked to elevated low-density lipoprotein (LDL) cholesterol, and one of the key genes that increases LDL cholesterol is Proprotein convertase subtilisin/kexin type 9 (PCSK9).
Arthur M Krieg
doaj   +3 more sources

Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathwayss⃞ [PDF]

Journal of Lipid Research, 2007
Endocytosis of LDL and modified LDL represents regulated and unregulated cholesterol delivery to macrophages. To elucidate the mechanisms of cellular cholesterol transport and egress under both conditions, various primary macrophages were labeled and ...
Ming-Dong Wang, Robert S. Kiss, Vivian Franklin, Heidi M. McBride, Stewart C. Whitman, Yves L. Marcel   +5 more
doaj   +3 more sources

Quo vadis, LDL cholesterol?

Advances in Laboratory Medicine, 2023
Cobos Andrés, Valdivielso Pedro
doaj   +3 more sources

When LDL Cholesterol Is Not LDL Cholesterol

JACC: Case Reports, 2022
LpX is a lipoprotein formed in cholestatic conditions and often erroneously reported as LDL-C. A low ApoB level can support the diagnosis of LpX. Treatment should not automatically focus on lowering serum lipid levels, but primarily on resolving the cause of cholestasis. (Level of Difficulty: Advanced.).
Lisa P.M. Huygen, Jan Westerink, Gerben C. Mol, Remy H.H. Bemelmans   +3 more
openaire   +3 more sources

Increased Platelet-derived Microparticles Counts is Correlated with Elevated Blood LDL Cholesterol in Acute Myocardial Infarction

Indonesian Biomedical Journal, 2022
BACKGROUND: Platelet-derived microparticles (PDMPs) and low-density lipoprotein (LDL) cholesterol are contributing factors to acute myocardial infarction (AMI).
Kelvin Supriami, Ira Puspitawati, Dyah Samti Mayasari, Anggoro Budi Hartopo   +3 more
doaj   +1 more source

Dyslipidemia and 10-year diabetes incidence in Japanese people: Population-based Panasonic cohort study 9

Frontiers in Endocrinology, 2022
Low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and LDL/HDL ratio have been associated with new-onset diabetes; however, their cut-off levels have not been determined.
Genki Kobayashi, Hiroshi Okada, Hiroshi Okada, Masahide Hamaguchi, Kazushiro Kurogi, Hiroaki Murata, Masato Ito, Michiaki Fukui   +7 more
doaj   +1 more source

Cardiovascular mortality after intensive LDL-Cholesterol lowering: Does baseline LDL-Cholesterol really matter?

American Journal of Preventive Cardiology, 2020
It remains controversial whether reductions in cardiovascular mortality after intensive lowering of low density lipoprotein cholesterol (LDL-C) depend on baseline LDL-C levels.
Safi U. Khan, Erin D. Michos
doaj   +1 more source

Mathematical modelling of the most effective goal of cholesterol-lowering treatment in primary prevention

BMJ Open, 2022
Objective To compare quantitatively different recommended goals for cholesterol-lowering treatment in the primary prevention of atherosclerotic cardiovascular disease (ASCVD).Design Outcomes at pretreatment low-density lipoprotein (LDL) cholesterol ...
Handrean Soran, Safwaan Adam, Paul Durrington, Zohaib Iqbal   +3 more
doaj   +1 more source

LDL-Cholesterol-Lowering Therapy [PDF]

, 2020
AbstractThe causal relation between elevated levels of LDL-C and cardiovascular disease has been largely established by experimental and clinical studies. Thus, the reduction of LDL-C levels is a major target for the prevention of cardiovascular disease.
Giuseppe Danilo Norata, Angela Pirillo, Alberico L. Catapano   +2 more
openaire   +3 more sources

Small Dense Low‐Density Lipoprotein Cholesterol Is the Most Atherogenic Lipoprotein Parameter in the Prospective Framingham Offspring Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Elevated plasma levels of direct low‐density lipoprotein cholesterol (LDL‐C), small dense LDL‐C (sdLDL‐C), low‐density lipoprotein (LDL) triglycerides, triglycerides, triglyceride‐rich lipoprotein cholesterol, remnant lipoprotein particle ...
Hiroaki Ikezaki, Elise Lim, L. Adrienne Cupples, Ching‐Ti Liu, Bela F. Asztalos, Ernst J. Schaefer   +5 more
doaj   +1 more source