Results 1 to 10 of about 529,150 (48)

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

Nature Biotechnology, 2021
Most known pathogenic point mutations in humans are C•G to T•A substitutions, which can be directly repaired by adenine base editors (ABEs). In this study, we investigated the efficacy and safety of ABEs in the livers of mice and cynomolgus macaques for ...
Tanja Rothgangl, Melissa K Dennis, Paulo J. C. Lin, Rurika Oka, D. Witzigmann, L. Villiger, W. Qi, M. Hrůzová, Lucas Kissling, Daniela Lenggenhager, Costanza Borrelli, S. Egli, Nina Frey, Noëlle Bakker, John A. Walker, A. Kadina, D. Victorov, Martin Pacesa, Susanne Kreutzer, Zacharias Kontarakis, A. Moor, M. Jinek, D. Weissman, M. Stoffel, R. van Boxtel, K. Holden, N. Pardi, B. Thöny, J. Häberle, Ying K. Tam, S. Semple, Gerald Schwank   +31 more
semanticscholar   +1 more source

A Ketogenic Low-Carbohydrate High-Fat Diet Increases LDL Cholesterol in Healthy, Young, Normal-Weight Women: A Randomized Controlled Feeding Trial

Nutrients, 2021
Ketogenic low-carbohydrate high-fat (LCHF) diets are popular among young, healthy, normal-weight individuals for various reasons. We aimed to investigate the effect of a ketogenic LCHF diet on low-density lipoprotein (LDL) cholesterol (primary outcome ...
J. Burén, M. Ericsson, N. Damasceno, Anna-Pya Sjödin   +3 more
semanticscholar   +1 more source

LDL-Cholesterol and Platelets: Insights into Their Interactions in Atherosclerosis

Life, 2021
Atherosclerosis and its complications, including acute coronary syndromes, are the major cause of death worldwide. The two most important pathophysiological mechanisms underlying atherosclerosis include increased platelet activation and increased low ...
A. Gąsecka, Sylwester Rogula, Ł. Szarpak, K. Filipiak   +3 more
semanticscholar   +1 more source

Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol.

New England Journal of Medicine, 2020
BACKGROUND Inclisiran inhibits hepatic synthesis of proprotein convertase subtilisin-kexin type 9. Previous studies suggest that inclisiran might provide sustained reductions in low-density lipoprotein (LDL) cholesterol levels with infrequent dosing ...
K. Ray, R. Wright, D. Kallend, W. Koenig, Lawrence A Leiter, F. Raal, Jenna A Bisch, T. Richardson, M. Jaros, P. Wijngaard, J. Kastelein   +10 more
semanticscholar   +1 more source

Total cholesterol/HDL-cholesterol ratio discordance with LDL-cholesterol and non-HDL-cholesterol and incidence of atherosclerotic cardiovascular disease in primary prevention: The ARIC study

European Journal of Preventive Cardiology, 2020
Aims The total cholesterol (TC)/high-density lipoprotein (HDL) cholesterol ratio may carry additional information not available in more commonly used single cholesterol measures.
Renato Quispe, M. Elshazly, Di Zhao, P. Toth, R. Puri, S. Virani, R. Blumenthal, S. Martin, S. Jones, E. Michos   +9 more
semanticscholar   +1 more source

Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Feedback control of cholesterol metabolism is essential for cell viability and prevention of heart attacks. Cells acquire cholesterol from receptor-mediated uptake of low-density lipoprotein, which delivers cholesterol to lysosomes. To exert
M. N. Trinh, Michael S. Brown, J. Goldstein, Jaeil Han, G. Vale, J. McDonald, J. Seemann, J. Mendell, F. Lu   +8 more
semanticscholar   +1 more source

Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol

New England Journal of Medicine, 2019
Background Short‐term studies have shown that bempedoic acid, an inhibitor of ATP citrate lyase, reduces levels of low‐density lipoprotein (LDL) cholesterol.
K. Ray, H. Bays, A. Catapano, N. Lalwani, L. Bloedon, L. Sterling, P. Robinson, C. Ballantyne   +7 more
semanticscholar   +1 more source

Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer’s disease and Parkinson’s disease: Mendelian randomisation study

British medical journal, 2017
Objective To test the hypothesis that low density lipoprotein (LDL) cholesterol due to genetic variation in the genes responsible for LDL cholesterol metabolism and biosynthesis(PCSK9 and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), respectively) is
M. Benn, B. Nordestgaard, R. Frikke-Schmidt, A. Tybjærg‐Hansen   +3 more
semanticscholar   +2 more sources

A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke.

New England Journal of Medicine, 2019
BACKGROUND The use of intensive lipid-lowering therapy by means of statin medications is recommended after transient ischemic attack (TIA) and ischemic stroke of atherosclerotic origin.
P. Amarenco, Jong－Suk Kim, J. Labreuche, Hugo Charles, J. Abtan, Y. Béjot, L. Cabrejo, J. Cha, G. Ducrocq, M. Giroud, C. Guidoux, Cristina Hobeanu, Yong-Jae Kim, B. Lapergue, Philippa C. Lavallée, Byung‐Chul Lee, K. Lee, D. Leys, M. Mahagne, E. Meseguer, N. Nighoghossian, F. Pico, Y. Samson, I. Sibon, P. Steg, S. Sung, P. Touboul, E. Touzé, O. Varenne, E. Vicaut, Nessima Yelles, E. Bruckert, Treat Stroke to Target Investigators   +32 more
semanticscholar   +1 more source

Quantifying Atherogenic Lipoproteins: Current and Future Challenges in the Era of Personalized Medicine and Very Low Concentrations of LDL Cholesterol. A Consensus Statement from EAS and EFLM.

Clinical Chemistry, 2018
BACKGROUND The European Atherosclerosis Society-European Federation of Clinical Chemistry and Laboratory Medicine Consensus Panel aims to provide recommendations to optimize atherogenic lipoprotein quantification for cardiovascular risk management ...
M. Langlois, M. Chapman, C. Cobbaert, S. Mora, A. Remaley, E. Ros, G. Watts, J. Borén, H. Baum, E. Bruckert, A. Catapano, O. Descamps, A. von Eckardstein, P. Kamstrup, G. Kolovou, F. Kronenberg, A. Langsted, K. Pulkki, N. Rifai, G. Sypniewska, O. Wiklund, B. Nordestgaard   +21 more
semanticscholar   +1 more source