Results 21 to 30 of about 604,324 (300)

LDL-Cholesterol-Lowering Therapy [PDF]

open access: yes, 2020
AbstractThe causal relation between elevated levels of LDL-C and cardiovascular disease has been largely established by experimental and clinical studies. Thus, the reduction of LDL-C levels is a major target for the prevention of cardiovascular disease.
Giuseppe Danilo Norata   +2 more
openaire   +3 more sources

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins [PDF]

open access: yes, 2014
Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation.
Herrington, D.M.   +624 more
core   +1 more source

Mathematical model for low density lipoprotein (LDL) endocytosis by hepatocytes [PDF]

open access: yes, 2008
Individuals with elevated levels of plasma low density lipoprotein (LDL) cholesterol (LDL-C) are considered to be at risk of developing coronary heart disease.
B. O’Malley   +20 more
core   +1 more source

Cholesterol absorption and synthesis related to low density lipoprotein metabolism during varying cholesterol intake in men with different apoE phenotypes.

open access: yesJournal of Lipid Research, 1992
The aim of the present study was, first, to investigate whether cholesterol (C) absorption, enhanced by cholesterol feeding, was related to synthesis of cholesterol, serum level of low density lipoprotein (LDL)-C, and receptor activity for LDL ...
H Gylling, TA Miettinen
doaj   +1 more source

Effect of Animal and Industrial Trans Fatty Acids on HDL and LDL Cholesterol Levels in Humans - A Quantitative Review [PDF]

open access: yes, 2010
Background: Trans fatty acids are produced either by industrial hydrogenation or by biohydrogenation in the rumens of cows and sheep. Industrial trans fatty acids lower HDL cholesterol, raise LDL cholesterol, and increase the risk of coronary heart ...
Wanders Anne J.   +13 more
core   +2 more sources

Effects of dietary cholesterol and fatty acids on plasma cholesterol level and hepatic lipoprotein metabolism.

open access: yesJournal of Lipid Research, 1990
The effects of dietary cholesterol and fatty acids on the plasma cholesterol level and rates of very low density lipoprotein (VLDL) cholesterol secretion and low density lipoprotein (LDL) transport through LDL receptors in the liver of the hamster were ...
H Ohtani   +8 more
doaj   +1 more source

Existing and emerging therapies for the treatment of familial hypercholesterolemia

open access: yesJournal of Lipid Research, 2021
Familial hypercholesterolemia (FH), an autosomal dominant disorder of LDL metabolism that is characterized by elevated LDL-cholesterol, is commonly encountered in patients with atherosclerotic coronary heart disease.
Robert S. Rosenson
doaj   +1 more source

LDL-C target attainment in the total cohort and stratified by risk as observed and simulated.

open access: yes, 2022
LDL-C concentrations are given as median (interquartile range). LDL-C: Low-density lipoprotein cholesterol. LLT: Lipid-lowering therapy.
Aikaterini Bilitou (5785471)   +3 more
core   +1 more source

Differences in the metabolism of oxidatively modified low density lipoprotein and acetylated low density lipoprotein by human endothelial cells: inhibition of cholesterol esterification by oxidatively modified low density lipoprotein.

open access: yesJournal of Lipid Research, 1989
The rate of degradation of oxidatively modified low density lipoprotein (Ox-LDL) by human endothelial cells was similar to that of unmodified low density lipoprotein (LDL), and was approximately 2-fold greater than the rate of degradation of acetylated ...
I Jialal, A Chait
doaj   +1 more source

Association between low-density lipoprotein cholesterol and sudden cardiac arrest in people with diabetes mellitus

open access: yesCardiovascular Diabetology, 2023
Background Dyslipidemia measured as low-density lipoprotein (LDL)-cholesterol is an established risk factor of cardiovascular disease, which is more pronounced in diabetes population.
Yun Gi Kim   +9 more
doaj   +1 more source

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