Results 41 to 50 of about 1,208,067 (297)

Clinical efficacy and safety of achieving very low LDL-cholesterol concentrations with the PCSK9 inhibitor evolocumab: a prespecified secondary analysis of the FOURIER trial.

The Lancet, 2017
BACKGROUND LDL cholesterol is a well established risk factor for atherosclerotic cardiovascular disease. How much one should or safely can lower this risk factor remains debated.
R. Giugliano, T. Pedersen, Jeong-Gun Park, G. D. de Ferrari, Z. Gaciong, R. Češka, K. Tóth, I. Gouni-Berthold, J. López-Miranda, F. Schiele, F. Mach, B. Ott, Estella Kanevsky, A. Pineda, R. Somaratne, S. Wasserman, A. Keech, P. Sever, M. Sabatine   +18 more
semanticscholar   +1 more source

Lipoprotein metabolism in familial hypercholesterolemia: Serial assessment using a one-step ultracentrifugation method

Practical Laboratory Medicine, 2015
Objectives: It is well known that familial hypercholesterolemia (FH) is a common inherited disorder that can markedly elevate the level of plasma LDL cholesterol.
Hayato Tada, Masa-aki Kawashiri, Atsushi Nohara, Akihiro Inazu, Hiroshi Mabuchi, Masakazu Yamagishi, Kenshi Hayashi   +6 more
doaj   +1 more source

Influence of an atherogenic diet on the structure of swine low density lipoproteins

Journal of Lipid Research, 1980
Five groups of three swine each were fed a basal diet supplemented with 15% tallow and either 0.0, 1.0, 1.5, 2.0%, or 2.5% cholesterol. The animals were studied over a period of 9 weeks to observe changes in plasma lipids and low density lipoproteins ...
H J Pownall, R L Jackson, R I Roth, A M Gotto, J R Patsch, F A Kummerow   +5 more
doaj   +1 more source

Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Feedback control of cholesterol metabolism is essential for cell viability and prevention of heart attacks. Cells acquire cholesterol from receptor-mediated uptake of low-density lipoprotein, which delivers cholesterol to lysosomes. To exert
M. N. Trinh, Michael S. Brown, Joseph L. Goldstein, Jaeil Han, G. Vale, Jeffrey G. McDonald, J. Seemann, Joshua T. Mendell, F. Lu   +8 more
semanticscholar   +1 more source

Interaction of aging and dietary fat in the regulation of low density lipoprotein transport in the hamster.

Journal of Lipid Research, 1989
These studies were undertaken to examine the effect of aging on low density lipoprotein (LDL) metabolism in the male hamster. When the hamsters were maintained on a low-cholesterol, low-triglyceride diet, rates of LDL transport in the various tissues of ...
D K Spady, J M Dietschy
doaj   +1 more source

Fenofibrate treatment increases human serum proprotein convertase subtilisin kexin type 9 levels

Journal of Lipid Research, 2010
Over the past several years, proprotein convertase subtilisin kexin type 9 (PCSK9) has gained significant attention as a key regulator of serum LDL-cholesterol (LDL-C) levels.
Jason S. Troutt, William E. Alborn, Guoqing Cao, Robert J. Konrad   +3 more
doaj   +1 more source

Cellular cholesterol efflux and cholesterol loading capacity of serum: effects of LDL-apheresis

Journal of Lipid Research, 2012
High LDL-cholesterol (LDL-C) characterizes familial hypercholesterolemia (FH) and familial combined hyperlipidemia (FCH). LDL-apheresis, used in these patients to reduce LDL-C levels, has been shown to also affect HDL levels and composition.
M.P. Adorni, F. Zimetti, M. Puntoni, F. Bigazzi, F. Sbrana, F. Minichilli, F. Bernini, N. Ronda, E. Favari, T. Sampietro   +9 more
doaj   +1 more source

The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial

The Lancet, 2011
Summary Background Lowering LDL cholesterol with statin regimens reduces the risk of myocardial infarction, ischaemic stroke, and the need for coronary revascularisation in people without kidney disease, but its effects in people with moderate-to-severe ...
C. Baigent, M. Landray, C. Reith, J. Emberson, David C. Wheeler, C. Tomson, Christoph Wanner, V. Krane, A. Cass, Jonathan Craig, B. Neal, Lixin Jiang, L. Hooi, Adeera Levin, L. Agodoa, M. Gaziano, B. Kasiske, Robert Walker, Z. A. Massy, B. Feldt-Rasmussen, U. Krairittichai, V. Ophascharoensuk, B. Fellström, Hallvard Holdaas, V. Tesař, Andrzej Wiecek, D. Grobbee, D. de Zeeuw, C. Grönhagen-Riska, T. Dasgupta, D. Lewis, W. Herrington, Marion M. Mafham, W. Majoni, K. Wallendszus, Richard Grimm, T. Pedersen, J. Tobert, J. Armitage, A. Baxter, C. Bray, Yi-Ping Chen, Zhengming Chen, M. Hill, C. Knott, Sarah Parish, D. Simpson, P. Sleight, A. Young, R. Collins   +49 more
semanticscholar   +1 more source

Biochemical and cytotoxic characteristics of an in vivo circulating oxidized low density lipoprotein (LDL-).

Journal of Lipid Research, 1994
Using ion exchange high pressure liquid chromatography, total plasma low density lipoprotein (LDL) from 30 hypercholesterolemic and 10 normocholesterolemic cynomolgus monkeys was subfractionated into unmodified LDL (n-LDL) and more negatively charged LDL
H.N. Hodis, D.M. Kramsch, P. Avogaro, G. Bittolo-Bon, G. Cazzolato, J. Hwang, H. Peterson, A. Sevanian   +7 more
doaj   +1 more source

Subcellular localization and quantification of cholesterol in cultured human fibroblasts exposed to human low density lipoprotein

Journal of Lipid Research, 1982
Subcellular localization of nonesterified cholesterol has been determined in normal human fibroblasts from cultures incubated with human low density lipoprotein (LDL).
H S Kruth, J Blanchette-Mackie, J Avigan, W Gamble, M Vaughan   +4 more
doaj   +1 more source