Results 131 to 140 of about 965,123 (374)

The Interplay of Sirtuin-1, LDL-Cholesterol, and HDL Function: A Randomized Controlled Trial Comparing the Effects of Energy Restriction and Atorvastatin on Women with Premature Coronary Artery Disease [PDF]

, 2022
Dalila Pinheiro Leal, Gustavo Henrique Ferreira Gonçalinho, Thauany Martins Tavoni, Karen Lika Kuwabara, Ana Paula Paccanaro, Fátima R. Freitas, Célia Maria Cássaro Strunz, Luı́z Antonio Machado César, Raul Cavalcante Maranhão, Antônio de Pádua Mansur   +9 more
openalex   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Rates of low density lipoprotein uptake and cholesterol synthesis are regulated independently in the liver.

Journal of Lipid Research, 1985
The relationship between rates of hepatic sterol synthesis and rates of hepatic low density lipoprotein (LDL) uptake (clearance) was studied in animals with high (rats), low (female hamsters), and very low (male hamsters) basal rates of hepatic sterol ...
D K Spady, S D Turley, J M Dietschy
doaj   +1 more source

A Potential Long-Acting LDL-Cholesterol–Lowering PCSK9 Monoclonal Antibody

, 2021
Yimin Cui, Xia Zhao, Litong Qi, Xin Li, Zhijun Huang, Guoping Yang, Lei Qian, Huan Deng, Haoyu Li, Yong Huo   +9 more
openalex   +1 more source

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

Nature Communications, 2014
Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation.
I. Postmus, S. Trompet, Harshal A Deshmukh, M. Barnes, Xiaohui Li, H. Warren, D. Chasman, K. Zhou, B. Arsenault, L. Donnelly, K. Wiggins, C. Avery, Paula J. Griffin, Q. Feng, K. Taylor, Guo Li, Daniel S. Evans, A. Smith, C. D. de Keyser, Andrew D. Johnson, A. D. de Craen, D. Stott, B. Buckley, I. Ford, R. Westendorp, P. Eline Slagboom, N. Sattar, P. Munroe, P. Sever, N. Poulter, A. Stanton, D. Shields, E. O'Brien, S. Shaw-Hawkins, Y. Ida Chen, D. Nickerson, Joshua D. Smith, Marie Pierre Dubé, S. Matthijs Boekholdt, G. Kees Hovingh, J. Kastelein, P. McKeigue, J. Betteridge, A. Neil, P. Durrington, A. Doney, Fiona Carr, A. Morris, M. McCarthy, L. Groop, E. Ahlqvist, J. Bis, K. Rice, N. Smith, T. Lumley, E. Whitsel, T. Stürmer, E. Boerwinkle, J. Ngwa, C. O’Donnell, R. Vasan, Wei-Qi Wei, R. Wilke, Ching‐Ti Liu, F. Sun, Xiuqing Guo, S. Heckbert, W. Post, N. Sotoodehnia, A. Arnold, J. Stafford, Jingzhong Ding, D. Herrington, S. Kritchevsky, G. Eiriksdottir, L. Launer, T. Harris, Audrey Y. Chu, Franco Giulianini, Jean G Macfadyen, B. J. Barratt, F. Nyberg, B. Stricker, A. Uitterlinden, A. Hofman, F. Rivadeneira, V. Emilsson, O. Franco, P. Ridker, V. Gudnason, Yongmei Liu, J. Denny, C. Ballantyne, J. Rotter, L. Adrienne Cupples, B. Psaty, Colin N. A. Palmer, J. Tardif, H. Colhoun, G. Hitman, R. Krauss, J. Wouter Jukema, M. Caulfield, Peter Ines Jenefer M. Elvira Matthew A. Juan P. Aiden Pa Donnelly Barroso Blackwell Bramon Brown Casas Corv, P. Donnelly, I. Barroso, J. Blackwell, E. Bramon, M. Brown, J. Casas, A. Corvin, P. Deloukas, A. Duncanson, Janusz Jankowski, H. Markus, C. Mathew, Colin N. A. Palmer, R. Plomin, A. Rautanen, S. Sawcer, R. Trembath, A. Viswanathan, N. Wood, Chris C. A. Gavin Céline Colin Garrett Eleni Matti Richa Spencer Band Bellenguez Freeman Hellenthal Giannou, C. Spencer, G. Band, C. Bellenguez, C. Freeman, G. Hellenthal, E. Giannoulatou, M. Pirinen, R. Pearson, A. Strange, Z. Su, Damjan Vukcevic, Cordelia Sarah E. Sarah Rhian Hannah Suzannah J. Serge Matt Langford Hunt Edkins Gwilliam Blackburn Bumpstead , C. Langford, S. Hunt, S. Edkins, R. Gwilliam, H. Blackburn, S. Bumpstead, S. Dronov, M. Gillman, Emma V. Gray, Naomi Hammond, Alagurevathi Jayakumar, O. T. McCann, J. Liddle, Simon C. Potter, Radhi Ravindrarajah, M. Ricketts, M. Waller, P. Weston, S. Widaa, P. Whittaker, C. G. J. M. M. A. A. M. I. C. C. A. Mathew Blackwell Brown Corvin McCarthy Spencer, M. McCarthy   +157 more
semanticscholar   +1 more source

The Gut Commensal Butyricimonas Virosa Modulates Gut Microbiota‐Dependent Thiamine Metabolism and Attenuates Mouse Steatotic Liver Disease

Advanced Science, EarlyView.
This study reveals that dietary stachyose enriches Butyricimonas virosa, effectively attenuating metabolic dysfunction‐associated steatotic liver disease (MASLD). Mechanistically, B. virosa enhances gut thiamine monophosphate synthesis, which elevates hepatic thiamine pyrophosphate levels.
Ningning He, Haoyu Wang, Zizhen Yang, Hui Li, Bei Liu, Kaiwei Chen, Zhinan Wu, Xinnan Zhao, Hewei Liang, Mengmeng Wang, Xiaofang Li, Yiyi Zhong, Haifeng Zhang, Liang Xiao, Karsten Kristiansen, Jixing Peng, Yuanqiang Zou, Shangyong Li   +17 more
wiley   +1 more source

Association of Serum LDL Cholesterol Level with Periodontitis among Patients Visiting a Tertiary-care Hospital

Journal of Nepal Medical Association, 2011
Introduction: High low-density lipoproteins (LDL) cholesterol is one of the major risk factors for cardiovascular disease. In recent years, some evidence has been presented that periodontitis,an infectious inflammatory condition of the periodontium, is ...
S Sharma, M Lamsal, SK Sharma, SR Niraula, B Koirala   +4 more
doaj   +1 more source

Maternal obesity is associated with the formation of small dense LDL and hypoadiponectinemia in the third trimester [PDF]

, 2013
Context: Maternal obesity is associated with high plasma triglyceride, poor vascular function, and an increased risk for pregnancy complications. In normal-weight pregnant women, higher triglyceride is associated with increased small, dense low-density ...
Brown, E.A., Caslake, M.J., Cooney, J., Freeman, D.J., Griffin, B.A., Meyer, B.J., Nilsson, S., Olivecrona, G., Ramsay, J.E., Stewart, F.M.   +9 more
core   +2 more sources

LDL-cholesterol signaling induces breast cancer proliferation and invasion

Lipids in Health and Disease, 2014
Lipids and cholesterol in particular, have long been associated with breast cancer (BC) onset and progression. However, the causative effects of elevated lipid levels and breast cancer remain largely undisclosed and were the subject of the present study ...
Catarina Rodrigues dos Santos, G. Domingues, Inês Matias, João Matos, I. Fonseca, José Mendes de Almeida, S. Dias   +6 more
semanticscholar   +1 more source

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source