Results 131 to 140 of about 297,289 (305)

Genetic variation at the apolipoprotein B gene and associations with coronary heart disease and its factors.

, 1996
PhDCoronary heart disease (CED) is the major cause of mortality in Western societies. The main risk factors are plasma lipoprotein concentrations, smoking, blood pressure and family history.
Rajput-Williams, Jayshri
core  

Pharmacogenetic GWAS meta-analysis of LDL cholesterol response to statins [PDF]

, 2014
Cardiolog
Jukema, J.W., Consortium, GIST, Trompet, S, Krauss, R.M., Krauss, RM, Trompet, S., Postmus, I., Tardif, J.C., Psaty, B.M., GIST Consortium, Barnes, MR, Tardif, JC, Hitman, G., Psaty, BM, Postmus, I, Barnes, M.R., Jukema, JW, Deshmukh, HA, Hitman, G, Deshmukh, H.A.   +19 more
core  

Genotypes relative to LDL-cholesterol distribution for 6 variants significantly associated with LDL-cholesterol levels after logistic regression.

, 2020
The 993 AWI-Gen individuals with low and high LDL-cholesterol are included in the plots. A-D: APOB rs6752026, LDLRAP1 rs12071264, PCSK9 rs45613943 and LDLR rs72658855 show how LDL-cholesterol levels decrease with presence of the minor allele.
Robyn Kerr (8478948), Michèle Ramsay (83973), Mahtaab Hayat (8478945), Charles N. Rotimi (8478951), Frederick J. Raal (8478954), Amy R. Bentley (7634120)   +5 more
core   +1 more source

Optimization of pharmaceutical research and development by early‐phase assessment of investigational medicinal products

British Journal of Clinical Pharmacology, EarlyView.
Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló, Attila Imre, Gábor Varga, Sándor Kovács, György Tímár, Balázs Nagy   +5 more
wiley   +1 more source

Rasio Monosit LDL Cholesterol dan Neutrofil LDL Cholesterol pada Penderita TB

This study analyzes the relationship between monocyte LDL cholesterol and LDL neutrophil values ​​in patients with pulmonary TB. The research method used is descriptive observational analytic with a cross-sectional study design.
Saquro, Abdan, Muslina, Muslina, Elisma, Elisma, Agraini, Agraini, Lestari, Uce   +4 more
core   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Atomically precise metal cluster enzymes for pathological tissue regeneration

BMEMat, EarlyView.
Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong, Zhifeng Shi, Mengqing Li, Jien Han, Haoyan Chen, Maofei Ran, Shaojian Zhong, Limin Ma, Chengyun Ning, Youzhun Fan, Zhenghua Tang, Peng Yu   +11 more
wiley   +1 more source

Plasma Exosome Metabolomics Reveal Stage‐Specific Alterations in Elderly Women With Premetabolic and Metabolic Syndrome

Chronic Diseases and Translational Medicine, EarlyView.
Shared differential metabolites identified across the three sample groups. (A) Venn diagram of differential metabolites between the two comparison groups; Based on the detected levels of these overlapping differential metabolites, (B) d‐Arabitol, (C) Triclosan, (D) Iloprost, (E) Tetracosanoic acid, and (F) Omeprazole sulfone. Box plots were constructed
Mengtao Qian, Dan Nie, Qianyi Gao, Xingbo Mo, Huan Zhang   +4 more
wiley   +1 more source

THE PROGRAM ON THE SURGICAL CONTROL OF THE HYPERLIPIDEMIAS (POSCH) AND THE LIPID REGULATORY HYPOTHESIS

European Medical Journal Cardiology, 2015
Background: The Lipid Regulatory Hypothesis (LRH) states that the best way to regress atherosclerotic plaque is to simultaneously decrease the cholesterol being transported into the arterial wall by low-density lipoprotein (LDL) and increase the ...
William E. Feeman, Jr, Stanley E. Williams, Henry Buchwald   +2 more
doaj  

Uncovering Coenzyme Q10‐Related Genetic Determinants of Statin‐Associated Muscle Symptoms: Evidence from the UK Biobank and the All of Us Research Program

Clinical Pharmacology &Therapeutics, EarlyView.
Statin‐associated muscle symptoms (SAMS) are frequent adverse effects of statin therapy and have been hypothesized to result from impaired coenzyme Q10 (CoQ10) biosynthesis. Although genetic determinants of CoQ10 levels have been reported, genome‐wide association studies (GWASs) conducted specifically in statin users are lacking. Moreover, direct CoQ10
Da Hoon Lee, Yoon‐A Park, Yubin Song, Ji‐Min Han, Kyung Hee Choi, Myeong Gyu Kim, Hye Sun Gwak   +6 more
wiley   +1 more source