Results 21 to 30 of about 965,123 (374)

Total cholesterol/HDL-cholesterol ratio discordance with LDL-cholesterol and non-HDL-cholesterol and incidence of atherosclerotic cardiovascular disease in primary prevention: The ARIC study

European Journal of Preventive Cardiology, 2020
Aims The total cholesterol (TC)/high-density lipoprotein (HDL) cholesterol ratio may carry additional information not available in more commonly used single cholesterol measures.
Renato Quispe, M. Elshazly, Di Zhao, P. Toth, R. Puri, S. Virani, R. Blumenthal, S. Martin, S. Jones, E. Michos   +9 more
semanticscholar   +1 more source

Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials [PDF]

, 2010
Background: Lowering of LDL cholesterol with standard statin regimens reduces the risk of occlusive vascular events in a wide range of individuals. We aimed to assess the safety and efficacy of more intensive lowering of LDL cholesterol with statin ...
Alsheikh-Ali, Ara, Armitage, Athyros, Ben-Yehuda, Cannon, Cannon, Chen, Colhoun, Davidson, Davidson, de Lemos, Downs, Fellstrom, Goldstein, Grundy, Holdaas, Iso, Kjekshus, Knopp, Koren, LaRosa, Nakamura, Pedersen, Pedersen, Ridker, Ridker, Sacks, Serruys, Sever, Shepherd, Shepherd, Stamler, Wanner   +33 more
core   +2 more sources

Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Feedback control of cholesterol metabolism is essential for cell viability and prevention of heart attacks. Cells acquire cholesterol from receptor-mediated uptake of low-density lipoprotein, which delivers cholesterol to lysosomes. To exert
M. N. Trinh, Michael S. Brown, J. Goldstein, Jaeil Han, G. Vale, J. McDonald, J. Seemann, J. Mendell, F. Lu   +8 more
semanticscholar   +1 more source

Effects of dietary cholesterol and fatty acids on plasma cholesterol level and hepatic lipoprotein metabolism.

Journal of Lipid Research, 1990
The effects of dietary cholesterol and fatty acids on the plasma cholesterol level and rates of very low density lipoprotein (VLDL) cholesterol secretion and low density lipoprotein (LDL) transport through LDL receptors in the liver of the hamster were ...
H Ohtani, K Hayashi, Y Hirata, S Dojo, K Nakashima, E Nishio, H Kurushima, M Saeki, G Kajiyama   +8 more
doaj   +1 more source

Existing and emerging therapies for the treatment of familial hypercholesterolemia

Journal of Lipid Research, 2021
Familial hypercholesterolemia (FH), an autosomal dominant disorder of LDL metabolism that is characterized by elevated LDL-cholesterol, is commonly encountered in patients with atherosclerotic coronary heart disease.
Robert S. Rosenson
doaj   +1 more source

Pathophysiology of elevated ascites fluid cholesterol in malignant ascites [PDF]

, 1992
The existence of marked elevations of ascitic fluid cholesterol has been observed in patients with peritoneal carcinomatosis compared to patients with cirrhosis and has been found useful in differential diagnosis.
Alexander L. Gerbes, Caselmann, Conrad, Dieter Jüngst, Garrison, Gerbes, Henderson, Henriksen, Hirabayashi, Hoefs, Hoefs, Jüngst, Kerscher, Lifshitz, Loiudice, Lopes-Virella, Mortensen, Pare, Polak, Prieto, Romette, Rovelstad, Röschlau, Suzuki, Weichselbaum, Weisweiler, Witte, Yining Xie   +27 more
core   +1 more source

Cholesterol absorption and synthesis related to low density lipoprotein metabolism during varying cholesterol intake in men with different apoE phenotypes.

Journal of Lipid Research, 1992
The aim of the present study was, first, to investigate whether cholesterol (C) absorption, enhanced by cholesterol feeding, was related to synthesis of cholesterol, serum level of low density lipoprotein (LDL)-C, and receptor activity for LDL ...
H Gylling, TA Miettinen
doaj   +1 more source

Metabolism of low-density lipoproteins by cultured hepatocytes from normal and homozygous familial hypercholesterolemic subjects [PDF]

, 1986
The profoundly elevated concentrations of low-density lipoproteins (LDL) present in homozygous familial hypercholesterolemia lead to symptomatic cardiovascular disease and death by early adulthood.
Brewer, HB, Demosky, SJ, Edge, SB, Gregg, RE, Hoeg, JM, Starzl, TE, Triche, T   +6 more
core   +1 more source

Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol

New England Journal of Medicine, 2019
Background Short‐term studies have shown that bempedoic acid, an inhibitor of ATP citrate lyase, reduces levels of low‐density lipoprotein (LDL) cholesterol.
K. Ray, H. Bays, A. Catapano, N. Lalwani, L. Bloedon, L. Sterling, P. Robinson, C. Ballantyne   +7 more
semanticscholar   +1 more source

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles. [PDF]

, 2017
Treatment of dyslipidemia patients with lipid-lowering drugs leads to a significant reduction in low-density lipoproteins (LDL) level and a low to moderate level of increase in high-density lipoprotein (HDL) cholesterol in plasma.
Alderete, Benjamin, Amento, Edward P, Kong, Raymond, Liu, David, Lundry, Jason, Madasamy, Shanmugavel, Robinson, J Paul, Wu, Alan HB   +7 more
core   +1 more source