Results 71 to 80 of about 604,324 (300)

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

LDL/HDL cholesterol ratio is associated with new-onset NAFLD in Chinese non-obese people with normal lipids: a 5-year longitudinal cohort study

Lipids in Health and Disease, 2021
Background Low-density lipoprotein to high density lipoprotein (LDL/HDL) cholesterol ratio has been reported to predict the risk of many metabolic diseases.
Yang Zou, Ling Zhong, Chong Hu, Mingchun Zhong, Nan Peng, Guotai Sheng   +5 more
doaj   +1 more source

Rasio Monosit LDL Cholesterol dan Neutrofil LDL Cholesterol pada Penderita TB [PDF]

This study analyzes the relationship between monocyte LDL cholesterol and LDL neutrophil values ​​in patients with pulmonary TB. The research method used is descriptive observational analytic with a cross-sectional study design.
Saquro, Abdan, Muslina, Muslina, Elisma, Elisma, Agraini, Agraini, Lestari, Uce, Muslina Muslina, Abdan Saquro, Agraini Agraini, Uce Lestari, Elisma Elisma   +9 more
core   +1 more source

Intuitive Modification of the Friedewald Formula for Calculation of LDL-Cholesterol

, 2022
BACKGROUND: High LDL-cholesterol (LDL-C) is an established risk factor for cardiovascular disease and is considered an important therapeutic target. It can be measured directly or calculated from the results of other lipid tests.
Ki Hoon Han, Han, Ki Hoon, Lee, Juhee, Hyunjung Gu, Won-Ki Min, Min, Won-Ki, Hong, Jinyoung, Sail Chun, Jinyoung Hong, Woochang Lee, Gu, Hyunjung, Lee, Woochang, Juhee Lee, Chun, Sail   +13 more
core   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Oxidised LDL, HDL cholesterol, LDL cholesterol levels in patients of coronary artery disease [PDF]

Indian Journal of Clinical Biochemistry, 2006
Coronary artery disease is a major cause of morbidity and has various risk factors. Lipid profile i.e. low HDL-cholesterol, high LDL cholesterol, high total cholesterol, high triglycerides playing important role in its causation. Recently interest has been shown in the oxidized fraction of LDL as one of the risk factors. In the present study 60 age and
Joya, Ghosh, T K, Mishra, Y N, Rao, S K, Aggarwal   +3 more
openaire   +2 more sources

Serum concentrations of total cholesterol, LDL-cholesterol, HDL-cholesterol, and TG (Mean ± SD).

, 2016
Serum concentrations of total cholesterol, LDL-cholesterol, HDL-cholesterol, and TG (Mean ± SD).
Xiaolan Ren (456299), Elisabete Weiderpass (49201), Chouji Zhang (834343), Jinen Xi (834345), Jing Zhang (23775), Yongrui Zhang (834344), Haoqiang Fan (456300), Pengfei Ge (383450), Caixia Dong (456298)   +8 more
core   +1 more source

Beyond LDL Cholesterol: the Role of LDL Particles and HDL [PDF]

, 2009
Currently available hypolipidemic treatments aim at reducing low density lipoprotein (LDL)-cholesterol. Unfortunately, cardiovascular events continue to occur despite LDL-lowering therapy with use of statins.
Pitsavos, Christos
core   +1 more source

DataSheet1_Diterpenoids inhibit ox-LDL-induced foam cell formation in RAW264.7 cells by promoting ABCA1 mediated cholesterol efflux.PDF

, 2023
Introduction: Atherosclerosis is the main cause of many cardiovascular diseases and contributes to morbidity and mortality worldwide. The formation of macrophage-derived foam cells plays a critical role in the early stage of atherosclerosis pathogenesis.
Xuewen Wu (11766797), Ruipu Zhang (4485034), Weilie Xiao (2735008), Guang Cao (2165698), Pengmin Shi (14392119), Qianlang Feng (14392122), Jinyuan Huang (14392125), Cheng Zhang (70708), Hongyu Ma (212546), Fei Fang (64051), Shuang Zhao (484057), Xinting Xu (14392128), Xu Ji (343848)   +12 more
core   +1 more source

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source