Results 1 to 10 of about 230,793 (312)

Primary structure comparison of the proposed low density lipoprotein (LDL) receptor binding domain of human and pig apolipoprotein B: implications for LDL-receptor interactions

Journal of Lipid Research, 1988
Apolipoprotein B (apoB) is the predominant protein in low density lipoprotein (LDL) and is responsible for LDL binding to the LDL receptor. Although the primary amino acid sequence of human apoB has been determined, little is known about the structural ...
D L Ebert, N Maeda, S W Lowe, J Hasler-Rapacz, J Rapacz, A D Attie   +5 more
doaj   +2 more sources

Functional characterization of 16 variants found in the LDL receptor gene. [PDF]

J Lipid Res
Konečná K, Přerovská T, Loja T, Fajkusová L, Koutná J, Kramárek M, Alves AC, Bourbon M, Freiberger T, Tichý L.   +9 more
europepmc   +2 more sources

An in vitro investigation of the effects of urolithins A and B on low-density lipoprotein uptake and its regulatory genes

Archives of Medical Science, 2023
Introduction This study aimed to evaluate the possible role of urolithin A (UA) and urolithin B (UB) on the mRNA expression levels of LDL receptor (LDLR) and PSCK9 genes, and also of the uptake of LDL particles in HepG2 cells.
Shiva Ganjali, Maryam Matbou Riahi, Khadijeh Mahboobnia, Milad Iranshahy, Maciej Banach, Ali Jangjoo, Sorour Ashari, Zahra Tayarani-Najaran, Amirhossein Sahebkar   +8 more
doaj   +1 more source

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in the treatment of dyslipidemia

Медицинский совет, 2021
Dyslipidemia makes a substantial contribution to the mortality as one of the leading pathogenetic factors for cardiovascular diseases. The nature and degree of the effect on the blood lipid spectrum may vary in the lipid-lowering drugs from different ...
A. A. Shikaleva, M. L. Maximov, N. M. Kiseleva   +2 more
doaj   +1 more source

Sequencing the Exon.4 of the LDL Receptor Gene in Patients with Familial Hypercholesterolemia in the Population of Bushehr, Southwestern Iran: the Possible New Mutations [PDF]

Journal of Advanced Biomedical Sciences, 2021
Background & Objective: Familial hypercholesterolemia (FH) is the most common genetic disease in the world and an autosomal dominant disease characterized by increased plasma cholesterol and low-density lipoprotein (LDL) concentrations.
Shima Parviz, Seyed Javad Hosseini, Ali Movahed   +2 more
doaj  

Regulation of low density lipoprotein receptor gene expression in HepG2 and Caco2 cells by palmitate, oleate, and 25-hydroxycholesterol

Journal of Lipid Research, 1995
Our in vivo studies in mice have shown that LDL-receptor gene expression is regulated differently in both liver and intestine by dietary cholesterol and dietary saturated fat.
R A Srivastava, H Ito, M Hess, N Srivastava, G Schonfeld   +4 more
doaj   +1 more source

Liver Transplantation to Provide Low-Density-Lipoprotein Receptors and Lower Plasma Cholesterol in a Child with Homozygous Familial Hypercholesterolemia [PDF]

, 1984
A six-year-old girl with severe hypercholesterolemia and atherosclerosis had two defective genes at the low-density-lipoprotein (LDL) receptor locus, as determined by biochemical studies of cultured fibroblasts.
Cummings, David W. Bilheimer, Goldstein, Joseph L. Goldstein, Michael S. Brown, Pittman, Schneider, Schneider, Scott M. Grundy, Thomas E. Starzl   +9 more
core   +1 more source

Besnoitia besnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDL uptake in host endothelial cells [PDF]

, 2008
Besnoitia besnoiti, an apicomplexan parasite of cattle being considered as emergent in Europe, replicates fast in host endothelial cells during acute infection and is in considerable need for energy, lipids and other building blocks for offspring ...
Silva, Liliana M. R., Lütjohann, Dieter, Hamid, Penny, Velasquez, Zahady D., Kerner, Katharina, Larrazabal, Camilo, Failing, Klaus, Hermosilla, Carlos, Taubert, Anja   +8 more
core   +2 more sources

Small dense low density lipoprotein has increased affinity for LDL receptor-independent cell surface binding sites: a potential mechanism for increased atherogenicity1

Journal of Lipid Research, 1998
Small dense low density lipoprotein (LDL) particles have altered apolipoprotein (apo) B conformation and lowered affinity for the LDL receptor (J. Biol. Chem. 1994. 269: 511–519).
Narmer F. Galeano, Maysoon Al-Haideri, Fannie Keyserman, Steven C. Rumsey, Richard J. Deckelbaum   +4 more
doaj   +1 more source

Metabolism of low-density lipoproteins by cultured hepatocytes from normal and homozygous familial hypercholesterolemic subjects [PDF]

, 1986
The profoundly elevated concentrations of low-density lipoproteins (LDL) present in homozygous familial hypercholesterolemia lead to symptomatic cardiovascular disease and death by early adulthood.
Brewer, HB, Demosky, SJ, Edge, SB, Gregg, RE, Hoeg, JM, Starzl, TE, Triche, T   +6 more
core   +1 more source