Results 161 to 170 of about 2,591,141 (428)

Mechanism of LDL binding and release probed by structure-based mutagenesis of the LDL receptor[S]

Journal of Lipid Research, 2010
The LDL receptor (LDL-R) mediates cholesterol metabolism in humans by binding and internalizing cholesterol transported by LDL. Several different molecular mechanisms have been proposed for the binding of LDL to LDL-R at neutral plasma pH and for its ...
Sha Huang, L. Henry, Y. K. Ho, H. Pownall, G. Rudenko   +4 more
semanticscholar   +1 more source

LC‐DAD‐MSn and HR‐LC‐QTOF analysis of Ziziphus budhensis leaves and evaluation of their in vitro and in vivo biological activities

Chemistry &Biodiversity, Accepted Article.
Ziziphus budhensis is a species described in 2015 in Nepal poorly studied for its phytochemical composition and possible bioactivities. In this study, six extracts were obtained from Z. budhensis leaves using ultrasound assisted extraction with solvents in increasing polarity.
Samjhana Bharati, Binita Maharjan, Timila Shrestha, Shyam Sharan Shrestha, Stefania Sut, Hari Prasad Devkota, Ram Lal Swagat Shrestha, Stefano Dall'Acqua   +7 more
wiley   +1 more source

Analysis of drug interactions with serum proteins and related binding agents by affinity capillary electrophoresis: A review

ELECTROPHORESIS, Volume 43, Issue 23-24, Page 2302-2323, December 2022., 2022
Abstract Biomolecules such as serum proteins can interact with drugs in the body and influence their pharmaceutical effects. Specific and precise methods that analyze these interactions are critical for drug development or monitoring and for diagnostic purposes.
Sadia Sharmeen, Isaac Kyei, Arden Hatch, David S. Hage   +3 more
wiley   +1 more source

Stabilization and cytoskeletal-association of LDL receptor mRNA are mediated by distinct domains in its 3′ untranslated region

Journal of Lipid Research, 1998
The mRNA encoding the human low density lipoprotein (LDL) receptor is transiently stabilized after phorbol ester treatment of HepG2 cells and has been shown to associate with components of the cytoskeleton in this cell line (G. M. Wilson, E. A.
G.M. Wilson, M.Z. Vasa, R.G. Deeley
doaj  

An antibody to the low‐density lipoprotein (LDL) receptor that partially inhibits the binding of LDL to cultured human fibroblasts [PDF]

, 1988
Sean J. P. GAVIGAN, Dilip D. Patel, Anne K. Soutar, Brian L. Knight   +3 more
openalex   +1 more source

A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice.

Journal of Clinical Investigation, 1998
Chronic macrophage-mediated inflammation is central to atherosclerosis. A role of the monocyte chemotactic and activating C-C chemokine JE/monocyte chemotactic protein-1 has been proposed.
W. Boisvert, R. Santiago, L. Curtiss, R. Terkeltaub   +3 more
semanticscholar   +1 more source

Structural, Spectroscopic, and Docking Analysis of N,O‐Donor Ligand Metal Complex Nanoparticles With Hypolipidemic Effects via Lipoprotein Lipase Activation in High‐Fat Diet Mice

Chemistry &Biodiversity, EarlyView.
Hypolipidemic influence of CETZ.2HCl‐(H1‐antihistamine) metal‐complexes on “C57Bl/6‐mice” fed high‐fat‐diet. ABSTRACT New Cd(II), Zn(II), and Cu(II) chelates with cetirizine.2HCl (CETZ.2HCl) in incidence of 1,10 phenanthroline monohydrate (Phen.H2O) were synthesized in search of new biologically active compounds.
Sherif M. Abd El‐Hamid, Safa W. Aziz, Amira A. Mohamed, Mohammed S. El‐Gedamy, Ahmed E. Salem, Soha F. Mohammed, Wael A. Zordok, Adriano Sofo, Mohamed A. Sabry, Sadeek A. Sadeek, Hazem S. Elshafie   +10 more
wiley   +1 more source

Role of receptor-independent low density lipoprotein transport in the maintenance of tissue cholesterol balance in the normal and WHHL rabbit.

Journal of Lipid Research, 1986
These studies were undertaken to determine the role of receptor-independent low density lipoprotein (LDL) transport in cholesterol balance across individual tissues and the whole animal.
D K Spady, M Huettinger, D W Bilheimer, J M Dietschy   +3 more
doaj  

Comparison of the internalization efficiency of LDL and transferrin receptors on L₂C guinea pig lymphocytes [PDF]

, 1986
Michel Vidal, Josette Sainte‐Marie, Jean R. Philippot, Alain Bienvenüe   +3 more
openalex   +1 more source

Lipid Metabolism and Immune Function: Chemical Tools for Insights into T‐Cell Biology

ChemBioChem, EarlyView.
This review explores how lipids regulate immune responses, particularly in T‐cell function. Advances in metabolomics and proteomics provide insights into lipid‐mediated immunity. Fluorescent lipids enable single‐cell analysis of lipid uptake and metabolism.
Luuk Reinalda, Mario van der Stelt, Sander Izaak van Kasteren   +2 more
wiley   +1 more source