Results 11 to 20 of about 127,223 (162)

LDL-receptor mutations in Europe [PDF]

Human Mutation, 2004
Familial hypercholesterolemia (FH) is a clinical definition for a remarkable increase of cholesterol serum concentration, presence of xanthomas, and an autosomal dominant trait of either increased serum cholesterol or premature coronary artery disease (CAD). The identification of the low-density lipoprotein (LDL)-receptor (LDLR) as the underlying cause
George V Z, Dedoussis, Hartmut, Schmidt, Janine, Genschel   +2 more
openaire   +2 more sources

Post-transcriptional regulation of retroviral vector-transduced low density lipoprotein receptor activity.

Journal of Lipid Research, 1990
We have reported the use of a retroviral vector to introduce the low density lipoprotein (LDL) receptor gene into receptor-deficient Watanabe heritable hyperlipidemic (WHHL) rabbit fibroblasts (Miyanohara, A., M. F. Sharkey, D. Steinberg, J. L.
MF Sharkey, A Miyanohara, RL Elam, T Friedmann, JL Witztum   +4 more
doaj   +1 more source

Relative importance of the LDL receptor and scavenger receptor class B in the β-VLDL-induced uptake and accumulation of cholesteryl esters by peritoneal macrophages

Journal of Lipid Research, 2000
We investigated the mechanism of β-very low density lipoprotein (β-VLDL)-induced foam cell formation derived from peritoneal macrophages from control mice and low density lipoprotein (LDL) receptor-deficient mice to elucidate the role of the LDL receptor
Nicole Herijgers, Miranda Van Eck, Suzanne J.A. Korporaal, Peter M. Hoogerbrugge, Theo J.C. Van Berkel   +4 more
doaj   +1 more source

Lipoprotein assembly and function in an evolutionary perspective

Biomolecular Concepts, 2010
Circulatory fat transport in animals relies on members of the large lipid transfer protein (LLTP) superfamily, including mammalian apolipoprotein B (apoB) and insect apolipophorin II/I (apoLp-II/I).
Van der Horst Dick J., Rodenburg Kees W.
doaj   +1 more source

Mitogenic stimulation alters the regulation of LDL receptor gene expression in human lymphocytes.

Journal of Lipid Research, 1990
To address the possibility that influences other than ambient cholesterol concentrations regulate low density lipoprotein (LDL) receptor expression, the effect of mitogenic activation on the levels of LDL receptor mRNA in human lymphocytes was examined ...
JA Cuthbert, PE Lipsky
doaj   +1 more source

Measurement of total hepatic low density lipoprotein receptor levels in the hamster.

Journal of Lipid Research, 1993
The ability to measure the total concentration of low density lipoprotein (LDL) receptors in hepatic tissues is of crucial importance to understanding changes in hepatic cholesterol metabolism.
PG Cosgrove, BJ Gaynor, HJ Harwood, Jr
doaj   +1 more source

Rapid fluorometric assay of LDL receptor activity by DiI-labeled LDL.

Journal of Lipid Research, 1993
DiI-LDL (3,3'-dioctadecylindocarbocyanine-low density lipoprotein) has been extensively used in morphological and microscopic studies of receptor-mediated metabolism of LDL in many cell lines.
ZF Stephan, EC Yurachek
doaj   +1 more source

Human Coronary Smooth Muscle Cells Internalize Versican-Modified LDL Through LDL Receptor–Related Protein and LDL Receptors [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2002
Versican-like proteoglycans are the main component of the intimal extracellular matrix interacting with low density lipoprotein (LDL). The aim of this study has been to investigate the receptors involved in versican-modified LDL uptake by human vascular smooth muscle cells (VSMCs). We have found that versican-LDL interaction leads to the following: (1)
Llorente-Cortés, Vicenta, Otero-Viñas, Marta, Hurt-Camejo, Eva, Martínez-González, José, Badimón Maestro, Lina   +4 more
openaire   +3 more sources

Regulation of macrophage apoE secretion and sterol efflux by the LDL receptor

Journal of Lipid Research, 2007
Factors that regulate apolipoprotein E (apoE) secretion by macrophages will have important effects on vessel wall lipid flux and atherosclerosis. Macrophages express the LDL receptor, which binds apoE with high affinity and could thereby affect the net ...
Danijela Lucic, Zhi Hua Huang, De Sheng Gu, Michael K. Altenburg, Nobuyo Maeda, Theodore Mazzone   +5 more
doaj   +1 more source

LDL Receptors in Keratinocytes

Journal of Investigative Dermatology, 1992
The presence of sufficient amounts of cholesterol in the epidermis is necessary for proper functioning of plasma membranes in the viable epidermal cell layers and also for the barrier quality of lipid intercellular bilayers of the stratum corneum. Cholesterol can be generated by local epidermal synthesis, or imported from the circulation as low-density
Ponec, Maria, te Pas, Marinus F.W, Havekes, Louis, Boonstra, Johannes, Mommaas, A Mieke, Vermeer, Bert Jan   +5 more
openaire   +2 more sources