Results 11 to 20 of about 2,591,141 (428)

A potential biomarker of cognitive impairment: The olfactory dysfunction and its genes expression

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1884-1897, December 2022., 2022
Abstract Objective Accumulation evidence has reported that olfactory impairment may be an essential clinical marker and predictor of mild cognitive impairment or Alzheimer's disease. Method Participants were enrolled in the population‐based, prospective study in Fuxin county, Liaoning province, China between 2019 and 2021.
Jiayi Song, Jiahui Xu, Wei Yuan, Ruixue Li, Hui Guo, Hanshu Gao, Cuiying Gu, Wenjing Feng, Yanan Ma, Haiqiang Guo, Zhaoqing Sun, Liqiang Zheng   +11 more
wiley   +1 more source

Sequencing the Exon.4 of the LDL Receptor Gene in Patients with Familial Hypercholesterolemia in the Population of Bushehr, Southwestern Iran: the Possible New Mutations [PDF]

Journal of Advanced Biomedical Sciences, 2021
Background & Objective: Familial hypercholesterolemia (FH) is the most common genetic disease in the world and an autosomal dominant disease characterized by increased plasma cholesterol and low-density lipoprotein (LDL) concentrations.
Shima Parviz, Seyed Javad Hosseini, Ali Movahed   +2 more
doaj  

LDL Receptors in Keratinocytes

Journal of Investigative Dermatology, 1992
The presence of sufficient amounts of cholesterol in the epidermis is necessary for proper functioning of plasma membranes in the viable epidermal cell layers and also for the barrier quality of lipid intercellular bilayers of the stratum corneum. Cholesterol can be generated by local epidermal synthesis, or imported from the circulation as low-density
Maria Ponec, Bert J. Vermeer, Louis Havekes, A. Mieke Mommaas, Johannes Boonstra, Marinus F W Te Pas   +5 more
openaire   +3 more sources

Mechanisms of dysregulation of low-density lipoprotein receptor expression in vascular smooth muscle cells by inflammatory cytokines [PDF]

, 2006
Objective - Although inflammation is a recognized feature of atherosclerosis, the impact of inflammation on cellular cholesterol homeostasis is unclear.
Ma, KL, Moorhead, JF, Powis, SH, Ruan, XZ, Tao, JL, Varghese, Z, Wheeler, DC   +6 more
core   +1 more source

Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients

Science immunology, 2016
PMN-MDSC in cancer patients can be distinguished from neutrophils by a genomic signature and by expression of the LOX-1 receptor. Stressing myeloid-derived suppressor cells in cancer Immunotherapies for cancer have shown promising results in part because
T. Condamine, George A. Dominguez, Je-in Youn, A. Kossenkov, Sridevi Mony, Kevin Alicea-Torres, E. Tcyganov, A. Hashimoto, Yulia Nefedova, Cindy Lin, S. Partlová, A. Garfall, D. Vogl, Xiaowei Xu, S. Knight, G. Malietzis, G. Lee, E. Eruslanov, S. Albelda, Xianwei Wang, J. Mehta, M. Bewtra, A. Rustgi, N. Hockstein, R. Witt, G. Masters, Brian Nam, D. Smirnov, Manuel A. Sepulveda, D. Gabrilovich   +29 more
semanticscholar   +1 more source

Liver Transplantation to Provide Low-Density-Lipoprotein Receptors and Lower Plasma Cholesterol in a Child with Homozygous Familial Hypercholesterolemia [PDF]

, 1984
A six-year-old girl with severe hypercholesterolemia and atherosclerosis had two defective genes at the low-density-lipoprotein (LDL) receptor locus, as determined by biochemical studies of cultured fibroblasts.
Cummings, David W. Bilheimer, Goldstein, Joseph L. Goldstein, Michael S. Brown, Pittman, Schneider, Schneider, Scott M. Grundy, Thomas E. Starzl   +9 more
core   +1 more source

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.

Journal of Clinical Investigation, 2000
Elimination of amyloid-ss peptide (Ass) from the brain is poorly understood. After intracerebral microinjections in young mice, (125)I-Ass(1-40) was rapidly removed from the brain (t(1/2)
Masayoshi Shibata, S. Yamada, S. R. Kumar, M. Calero, J. Bading, B. Frangione, D. Holtzman, C. Miller, D. Strickland, J. Ghiso, B. Zlokovic   +10 more
semanticscholar   +1 more source

A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function [PDF]

Human Molecular Genetics, 2013
A common synonymous single nucleotide polymorphism in exon 12 of the low-density lipoprotein receptor (LDLR) gene, rs688, has been associated with increased plasma total and LDL cholesterol in several populations. Using immortalized lymphoblastoid cell lines from a healthy study population, we confirmed an earlier report that the minor allele of rs688 ...
Gao, Feng, Ihn, Hansel E, Medina, Marisa W, Krauss, Ronald M   +3 more
openaire   +4 more sources

Molecular genetics of the LDL receptor gene in familial hypercholesterolemia

Human Mutation, 1992
The low density lipoprotein (LDL) receptor is a cell surface transmembrane protein that mediates the uptake and lysosomal degradation of plasma LDL, thereby providing cholesterol to cells.
H. Hobbs, Michael S. Brown, J. Goldstein
semanticscholar   +1 more source

Atomistic characterization of the SiO2 high-density liquid/low-density liquid interface [PDF]

, 2022
The equilibrium silica liquid-liquid interface between the high-density liquid (HDL) phase and the low-density liquid (LDL) phase is examined using molecular-dynamics simulation. The structure, thermodynamics, and dynamics within the interfacial region are characterized in detail and compared with previous studies on the liquid-liquid phase transition (
arxiv   +1 more source