Results 21 to 30 of about 230,793 (312)

Genetic obesity increases pancreatic expression of mitochondrial proteins which regulate cholesterol efflux in BRIN-BD11 insulinoma cells [PDF]

, 2019
Pancreatic β-cells are sensitive to fluctuations in cholesterol content, which can damage the insulin secretion pathway, contributing to the aetiology of type 2 diabetes mellitus.
Caridis, Anna Maria, Dolan, Sharron, Graham, Annette, Lightbody, Richard J., Tarlton, Jamie M.R.   +4 more
core   +1 more source

Relative importance of the LDL receptor and scavenger receptor class B in the β-VLDL-induced uptake and accumulation of cholesteryl esters by peritoneal macrophages

Journal of Lipid Research, 2000
We investigated the mechanism of β-very low density lipoprotein (β-VLDL)-induced foam cell formation derived from peritoneal macrophages from control mice and low density lipoprotein (LDL) receptor-deficient mice to elucidate the role of the LDL receptor
Nicole Herijgers, Miranda Van Eck, Suzanne J.A. Korporaal, Peter M. Hoogerbrugge, Theo J.C. Van Berkel   +4 more
doaj   +1 more source

Post-transcriptional regulation of retroviral vector-transduced low density lipoprotein receptor activity.

Journal of Lipid Research, 1990
We have reported the use of a retroviral vector to introduce the low density lipoprotein (LDL) receptor gene into receptor-deficient Watanabe heritable hyperlipidemic (WHHL) rabbit fibroblasts (Miyanohara, A., M. F. Sharkey, D. Steinberg, J. L.
MF Sharkey, A Miyanohara, RL Elam, T Friedmann, JL Witztum   +4 more
doaj   +1 more source

Mitogenic stimulation alters the regulation of LDL receptor gene expression in human lymphocytes.

Journal of Lipid Research, 1990
To address the possibility that influences other than ambient cholesterol concentrations regulate low density lipoprotein (LDL) receptor expression, the effect of mitogenic activation on the levels of LDL receptor mRNA in human lymphocytes was examined ...
JA Cuthbert, PE Lipsky
doaj   +1 more source

CXCL16 and oxLDL are induced in the onset of diabetic nephropathy [PDF]

, 2009
Diabetic nephropathy (DN) is a major cause of end-stage renal failure worldwide. Oxidative stress has been reported to be a major culprit of the disease and increased oxidized low density lipoprotein (oxLDL) immune complexes were found in patients with ...
Abdel-Aziz, Abdel-Aziz H., Abdel-Bakky, Mohamed Sadek, Amann, Kerstin Ute, Beckmann, Janet, Doberstein, Kai, Doller, Anke, El Sayed, El Sayed M., Gutwein, Paul, Kämpfer-Kolb, Nicole, Pfeilschifter, Josef Martin, Schramme, Anja, Schäfer, Liliana   +11 more
core   +1 more source

Measurement of total hepatic low density lipoprotein receptor levels in the hamster.

Journal of Lipid Research, 1993
The ability to measure the total concentration of low density lipoprotein (LDL) receptors in hepatic tissues is of crucial importance to understanding changes in hepatic cholesterol metabolism.
PG Cosgrove, BJ Gaynor, HJ Harwood, Jr
doaj   +1 more source

Regulation of macrophage apoE secretion and sterol efflux by the LDL receptor

Journal of Lipid Research, 2007
Factors that regulate apolipoprotein E (apoE) secretion by macrophages will have important effects on vessel wall lipid flux and atherosclerosis. Macrophages express the LDL receptor, which binds apoE with high affinity and could thereby affect the net ...
Danijela Lucic, Zhi Hua Huang, De Sheng Gu, Michael K. Altenburg, Nobuyo Maeda, Theodore Mazzone   +5 more
doaj   +1 more source

Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival [PDF]

, 2017
LDL receptor-related proteins (LRPs) are transmembrane receptors involved in endocytosis, cell-signaling, and trafficking of other cellular proteins. Considerable work has focused on LRPs in the fields of vascular biology and neurobiology.
Gilder, Andrew S., Gonias, Steven L., Karimi-Mostowfi, Nicki, Mantuano, Elisabetta, Murray, Sarah S.   +4 more
core   +3 more sources

Rapid fluorometric assay of LDL receptor activity by DiI-labeled LDL.

Journal of Lipid Research, 1993
DiI-LDL (3,3'-dioctadecylindocarbocyanine-low density lipoprotein) has been extensively used in morphological and microscopic studies of receptor-mediated metabolism of LDL in many cell lines.
ZF Stephan, EC Yurachek
doaj   +1 more source

Non-sterol regulation of low density lipoprotein receptor gene expression in T cells

Journal of Lipid Research, 1994
Non-sterol regulation of low density lipoprotein (LDL) receptor gene expression was examined in a mitogen-responsive human T cell line. Stimulation of the leukemic T cell line Jurkat with the phorbol ester phorbol 12-myristate 13-acetate (PMA) and the ...
R S Makar, P E Lipsky, J A Cuthbert
doaj   +1 more source