Results 21 to 30 of about 2,625,160 (406)
Oxidized low-density lipoprotein inhibits hepatitis C virus cell entry in human hepatoma cells. [PDF]
, 2006 Cell entry of hepatitis C virus, pseudoparticles (HCVpp) and cell culture grown virus (HCVcc), requires the interaction of viral glycoproteins with CD81 and other as yet unknown cellular factors.
Boullier, Agnès +6 more
core +1 more source
ELISA measurement of LDL receptors
Journal of Lipid Research, 1990 An enzyme-linked immunosorbent assay was developed for measurement of low density lipoprotein (LDL) receptors. A monospecific polyclonal antibody to LDL receptor purified from rat liver that reacted with rat, mouse, canine, and human LDL receptor was used.
Allen D. Cooper +3 more
openaire +4 more sources
Scientific Reports, 2018 CRISPR/Cas gene studies were conducted in HeLa cells where either PGRMC1, TMEM97 or both proteins were removed via gene editing. A series of radioligand binding studies, confocal microscopy studies, and internalization of radiolabeled or fluorescently ...
A. Riad +8 more
semanticscholar +1 more source
Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein [PDF]
, 2006 Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases.
Siess, Wolfgang
core +1 more source
Journal of Lipid Research, 2016 Lipoprotein (a) [Lp(a)] is independently associated with CVD risk. Evolocumab, a monoclonal antibody (mAb) to proprotein convertase subtilisin/kexin type 9 (PCSK9), decreases Lp(a). The potential mechanisms were assessed.
F. Raal +16 more
semanticscholar +1 more source
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor [PDF]
, 2002 Oxidatively modified low-density lipoprotein (ox-LDL) leads to endothelial activation, dysfunction and injury. Recently, a novel lectin-like receptor for ox-LDL (LOX-1) has been identified, primarily in the endothelial cells, and it allows uptake of ox ...
Li, Dayuan, Mehta, Jawahar L
core +1 more source
High bone density due to a mutation in LDL-receptor-related protein 5.
New England Journal of Medicine, 2002 BACKGROUND Osteoporosis is a major public health problem of largely unknown cause. Loss-of-function mutations in the gene for low-density lipoprotein receptor-related protein 5 (LRP5), which acts in the Wnt signaling pathway, have been shown to cause ...
L. Boyden +8 more
semanticscholar +1 more source
Unpacking and understanding the impact of proprotein convertase subtilisin/kexin type 9 inhibitors on apolipoprotein B metabolism [PDF]
, 2017 No abstract ...
Packard, Chris J.
core +1 more source
СОХРАНЕНИЕ РЕЦЕПТОРОВ ЛПНП — НОВЫЙ ПОДХОД К ТЕРАПИИ ГИПЕРЛИПИДЕМИИ
Архивъ внутренней медицины, 2013 LDL receptor plays a key role in the metabolism of LDL cholesterol. It have been shown that proprotein convertase subtlisin/kexin type 9 is essential for post-transcriptional regulatation of the cell surface expression of the LDL receptor by ...
С. С. Бажан
doaj +1 more source
Heparan sulfate proteoglycans present PCSK9 to the LDL receptor
Nature Communications, 2017 Coronary artery disease is the main cause of death worldwide and accelerated by increased plasma levels of cholesterol-rich low-density lipoprotein particles (LDL).
Camilla Gustafsen +13 more
semanticscholar +1 more source