Results 51 to 60 of about 127,223 (162)

Low density lipoprotein metabolism in the normal to moderately elevated range of plasma cholesterol: comparisons with familial hypercholesterolemia

Journal of Lipid Research, 1983
Low density lipoprotein (LDL) metabolism was investigated using a pulse injection of 125I-labeled LDL in 20 subjects who did not have familial hypercholesterolemia (FH) (plasma cholesterol 160-297 mg/dl) and in 9 subjects who did have heterozygous FH ...
L A Simons, S Balasubramaniam, J Holland
doaj   +1 more source

Multiple processes are involved in the uptake of chylomicron remnants by mouse peritoneal macrophages

Journal of Lipid Research, 1998
The processes responsible for the uptake of chylomicron remnants by macrophages were investigated using freshly isolated cells from low density lipoprotein (LDL) receptor, very low density lipoprotein (VLDL) receptor and apolipoprotein E knockout mice ...
Yoshio Fujioka, Allen D. Cooper, Loren G. Fong   +2 more
doaj   +1 more source

Chylomicron remnant uptake in the livers of mice expressing human apolipoproteins E3, E2 (Arg158→Cys), and E3-Leiden

Journal of Lipid Research, 2004
Apolipoprotein E2 (apoE2) and apoE3-Leiden cause chylomicron remnant accumulation (type III hyperlipidemia). However, the degree of dyslipidemia and its penetrance are different in humans and mice.
Sung-Joon Lee, Itamar Grosskopf, Sungshin Y. Choi, Allen D. Cooper   +3 more
doaj   +1 more source

LDL transcytosis passes through the trans-Golgi network and requires Rab10

Journal of Lipid Research
Atherosclerosis begins with the subendothelial retention of LDLs from the circulation. While LDL transcytosis across the endothelium is mediated by scavenger receptor class B type I and activin-like kinase receptor 1 and is usually independent of LDL ...
Tse Wing Winnie Ho, Changsen Wang, Warren L. Lee   +2 more
doaj   +1 more source

Chondroitin sulfate-modified LDL induces increased cholesteryl ester synthesis and down-regulation of LDL receptors in smooth muscle cells and macrophages

Open Life Sciences, 2006
Tircol Magdalena, Tirziu Daniela, Simionescu Maya   +2 more
doaj   +1 more source

The LDL receptor is regulated by membrane cholesterol as revealed by fluorescence fluctuation analysis. [PDF]

Biophys J, 2023
Morales SV, Mahmood A, Pollard J, Mayne J, Figeys D, Wiseman PW.   +5 more
europepmc   +1 more source

Soluble LDL-receptor is induced by TNF-α and inhibits hepatocytic clearance of LDL-cholesterol. [PDF]

J Mol Med (Berl), 2023
Zegeye MM, Nakka SS, Andersson JSO, Söderberg S, Ljungberg LU, Kumawat AK, Sirsjö A.   +6 more
europepmc   +1 more source

Sailing the Uncharted Waters of Familial Hypercholesterolemia LDL Receptor Genetic-Related Variants: Land in Sight? [PDF]

JACC Basic Transl Sci, 2023
Santos RD.
europepmc   +1 more source

Effect of type 2 diabetes on the inducible degrader of LDL receptor. [PDF]

J Lipid Res, 2023
Lam S, Lui DTW, Shiu SWM, Wong Y, Tan KCB.   +4 more
europepmc   +1 more source

Carbon Nanodots Attenuate Lipid Peroxidation in the LDL Receptor Knockout Mouse Brain. [PDF]

Antioxidants (Basel), 2023
Erikson KM, El-Khouri K, Petric R, Tang C, Chen J, Vasquez DEC, Fordahl SC, Jia Z.   +7 more
europepmc   +1 more source