Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders. [PDF]
, 2016 Apolipoprotein (apo) E was initially described as a lipid transport protein and major ligand for low density lipoprotein (LDL) receptors with a role in cholesterol metabolism and cardiovascular disease.
Mahley, Robert W
core +1 more source
Nephrology, Dialysis and Transplantation, 2014 BACKGROUND Nephrotic syndrome (NS) leads to elevation of serum total and LDL cholesterol. This is largely due to impaired LDL clearance, which is caused by hepatic LDL receptor (LDLR) deficiency despite normal LDLR mRNA expression, pointing to a post ...
Shuman Liu, N. Vaziri
semanticscholar +1 more source
Rethinking Soft Label in Label Distribution Learning Perspective [PDF]
arXiv, 2023 The primary goal of training in early convolutional neural networks (CNN) is the higher generalization performance of the model. However, as the expected calibration error (ECE), which quantifies the explanatory power of model inference, was recently introduced, research on training models that can be explained is in progress.
arxiv
Parametric Linear Dynamic Logic [PDF]
EPTCS 161, 2014, pp. 60-73, 2014 We introduce Parametric Linear Dynamic Logic (PLDL), which extends Linear Dynamic Logic (LDL) by temporal operators equipped with parameters that bound their scope. LDL was proposed as an extension of Linear Temporal Logic (LTL) that is able to express all $\omega$-regular specifications while still maintaining many of LTL's desirable properties like ...
arxiv +1 more source
LDL Receptor and ApoE Are Involved in the Clearance of ApoM-associated Sphingosine 1-Phosphate*
Journal of Biological Chemistry, 2014 Background: A positive correlation exists between sphingosine 1-phosphate (S1P) and LDL cholesterol. Results: Hepatic LDL receptor overexpression decreased plasma S1P together with apoM in wild-type mice, but not in apoE-deficient mice.
M. Kurano +5 more
semanticscholar +1 more source
Three patients with homozygous familial hypercholesterolemia: Genomic sequencing and kindred analysis. [PDF]
, 2019 BackgroundHomozygous Familial Hypercholesterolemia (HoFH) is an inherited recessive condition associated with extremely high levels of low-density lipoprotein (LDL) cholesterol in affected individuals.
Balamir, Melek +15 more
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Besnoitia besnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDL uptake in host endothelial cells [PDF]
, 2008 Besnoitia besnoiti, an apicomplexan parasite of cattle being considered as emergent in Europe, replicates fast in host endothelial cells during acute infection and is in considerable need for energy, lipids and other building blocks for offspring ...
Silva, Liliana M. R. +8 more
core +2 more sources
Inaccurate Label Distribution Learning [PDF]
arXiv, 2023 Label distribution learning (LDL) trains a model to predict the relevance of a set of labels (called label distribution (LD)) to an instance. The previous LDL methods all assumed the LDs of the training instances are accurate. However, annotating highly accurate LDs for training instances is time-consuming and very expensive, and in reality the ...
arxiv
Towards Genetic Prediction of Coronary Heart Disease in Familial Hypercholesterolemia [PDF]
, 2009 Familial hypercholesterolemia (FH) is an autosomal dominant disorder of lipid metabolism caused by mutations in the gene coding for the low-density lipoprotein (LDL) receptor.
Net, J.B. (Jeroen) van der
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Long-term efficacy and safety of the microsomal triglyceride transfer protein inhibitor lomitapide in patients with homozygous familial hypercholesterolemia [PDF]
, 2017 Homozygous familial hypercholesterolemia is a genetic disorder characterized by low-density lipoprotein (LDL)-receptor dysfunction, markedly elevated levels of LDL-cholesterol (LDL-C) and premature atherosclerosis. Patients are often poorly responsive
Averna M. R. +14 more
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