Results 221 to 230 of about 37,789 (262)

Prelamin A in an <i>Lmna</i> ^L648R/L648R Mouse Model Does Not Promote Atherosclerosis or Vascular Smooth Muscle Loss. [PDF]

Arterioscler Thromb Vasc Biol
Wang Y, Joseph LC, Östlund C, Kuriakose G, Hsu W, Michaelis S, Worman HJ.   +6 more
europepmc   +1 more source

Regulation of intestinal LDLR by the LXR-IDOL axis [PDF]

Atherosclerosis, 2020
Background and aims: Cholesterol metabolism is tightly regulated by transcriptional and post-transcriptional mechanisms. Accordingly, dysregulation of cholesterol metabolism is a major risk factor for the development of coronary artery disease and ...
Noam Zelcer, Saskia Scheij, Roelof Ottenhoff   +2 more
exaly   +5 more sources

Triciribine increases LDLR expression and LDL uptake through stabilization of LDLR mRNA

Scientific Reports, 2018
AbstractLow-density lipoprotein receptor (LDLR) is a key regulator of the metabolism of plasma low-density lipoprotein cholesterol (LDL-C), the elevated levels of which are associated with an increased risk of cardiovascular disease. Therefore, enhancing LDLR expression represents a potent treatment strategy for hypercholesterolemia.
Katrine Bjune
exaly   +3 more sources

Akt2/LDLr double knockout mice display impaired glucose tolerance and develop more complex atherosclerotic plaques than LDLr knockout mice

Cardiovascular Research, 2014
To characterize the phenotype of Akt2/low-density-lipoprotein receptor double knockout (dKO) (Akt2/LDLr dKO) mice with respect to insulin resistance and features of atherosclerotic plaque progression.
Dallinga-Thie G M, Erik Stroes, Jan von der Thüsen   +2 more
exaly   +2 more sources

Berberine-induced LDLR up-regulation involves JNK pathway

Biochemical and Biophysical Research Communications, 2007
Berberine, an herbal alkaloid, has been reported to have a lipid lowering effect by stabilizing hepatic LDLR mRNA in an ERK-dependent manner rather than promoting transcriptional activity.
Yangsoo Jang, Hyun-Young Park, Hyun-Joung Lim   +2 more
exaly   +2 more sources

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Analysis of LDLR variants from homozygous FH patients carrying multiple mutations in the LDLR gene

Atherosclerosis, 2017
Familial hypercholesterolemia (FH) is an autosomal dominant disease with widespread global prevalence that partially accounts for the high prevalence of premature coronary heart disease. Although the majority of research on FH has focused on single heterozygous LDLR mutations, there have been limited reports of double LDLR mutations on the same ...
Lu-Ya Wang, Long Jiang, Helena Ostolaza   +2 more
exaly   +3 more sources

LDLR missense variants disturb structural conformation and LDLR activity in T-lymphocytes of Familial hypercholesterolemia patients

Gene, 2023
Familial hypercholesterolemia (FH) is caused by deleterious mutations in the LDLR that increase markedly low-density lipoprotein (LDL) cholesterol and cause premature atherosclerotic cardiovascular disease. Functional effects of pathogenic LDLR variants identified in Brazilian FH patients were assessed using in vitro and in silico studies.
Thais Kristini Almendros, Barbosa, Rosario Dominguez Crespo, Hirata, Glaucio Monteiro, Ferreira, Jéssica Bassani, Borges, Victor Fernandes de, Oliveira, Renata, Gorjão, Elisangela Rodrigues da Silva, Marçal, Rodrigo Marques, Gonçalves, André Arpad, Faludi, Renata Caroline Costa de, Freitas, Carolina, Dagli-Hernandez, Raul Hernandes, Bortolin, Gisele Medeiros, Bastos, Tania Cristina, Pithon-Curi, Helena Bonciani, Nader, Mario Hiroyuki, Hirata   +15 more
openaire   +2 more sources

AAV8- LDLR Gene Therapy in Ldlr -KO and Homozygous Ldlr p.W483X Mice

Human Gene Therapy
The low-density lipoprotein receptor (LDLR) plays a crucial role in cholesterol regulation and lipoprotein transport. Variations in the LDLR gene can cause familial hypercholesterolemia (FH), with homozygous familial hypercholesterolemia (HoFH) being the most severe form.
Qingao Li, Muyun Tang, Ye Jin, Gengchen Su, Yufan Li, Kaide Ju, Shijie Zhang, Shuyang Zhang, Xiaodong Luan   +8 more
openaire   +2 more sources

Validation of LDLr Activity as a Tool to Improve Genetic Diagnosis of Familial Hypercholesterolemia: A Retrospective on Functional Characterization of LDLr Variants [PDF]

International Journal of Molecular Sciences, 2018
Familial hypercholesterolemia (FH) is an autosomal dominant disorder characterized by high blood-cholesterol levels mostly caused by mutations in the low-density lipoprotein receptor (LDLr). With a prevalence as high as 1/200 in some populations, genetic screening for pathogenic LDLr mutations is a cost-effective approach in families classified as ...
Helena Ostolaza, Cesar Martin, Kepa B Uribe   +2 more
exaly   +5 more sources