Results 231 to 240 of about 37,789 (262)

PCSK9 Promotes LDLR Degradation by Preventing SNX17-Mediated LDLR Recycling

Circulation
BACKGROUND: Low-density lipoprotein (LDL) is internalized into cells mainly through LDLR (LDL receptor)–mediated endocytosis. In an acidic endosome, LDLR is released from LDL and recycles back to the cell surface, whereas LDL is left in the endosome and degraded in the lysosome.
YangYang Guan, Xiaomin Liu, Zetian Yang, Xinyu Zhu, Min Liu, Mingkun Du, Xiaowei Pan, Yan Wang   +7 more
openaire   +2 more sources

Role of sEH R287Q in LDLR expression, LDL binding to LDLR and LDL internalization in BEL-7402 cells

Gene, 2018
Familial hypercholesterolemia (FH) is an autosomal dominant disorder of cholesterol metabolism. Three recognized genes (LDLR, APOB and PCSK9) present in only 20-30% of patients with possible FH cases. Additional FH-causing genes need to be explored. The present study found an isolated gene change, sEH R287Q, in a core family of FH.
Ling, Tang, Guoliang, Wang, Long, Jiang, Panpan, Chen, Wei, Wang, Juan, Chen, Luya, Wang   +6 more
openaire   +2 more sources

Post-transcriptional Regulation of LDLR

2023
Elevated plasma LDL cholesterol is the main risk factor in cardiovascular disease (CVD), the leading cause of death in the United States. Cholesterol levels are regulated by complex feedback mechanisms that help maintain cellular and plasma cholesterol levels in check.
openaire   +1 more source

A Variant in LDLR Is Associated With Abdominal Aortic Aneurysm

Circulation: Cardiovascular Genetics, 2013
Background— Abdominal aortic aneurysm (AAA) is a common cardiovascular disease among older people and demonstrates significant heritability. In contrast to similar complex diseases, relatively few genetic associations with AAA have been confirmed. We reanalyzed our genome-wide study and carried through to replication suggestive
Bradley, Declan T., Hughes, Anne E, Badger, Stephen A, Jones, Gregory T, Harrison, Seamus C, Wright, Benjamin J, Bumpstead, Suzannah, Baas, Annette F, Gretarsdottir, Solveig, Burnand, Kevin, Child, Anne H, Clough, Rachel E, Cockerill, Gillian, Hafez, Hany, Scott, D Julian A, Ariëns, Robert A S, Johnson, Anne, Sohrabi, Soroush, Smith, Alberto, Thompson, Matthew M, van Bockxmeer, Frank M, Waltham, Matthew, Matthiasson, Stefan E, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Blankensteijn, Jan D, Teijink, Joep A W, Wijmenga, Cisca, de Graaf, Jacqueline, Kiemeney, Lambertus A, Wild, John B, Edkins, Sarah, Gwilliam, Rhian, Hunt, Sarah E, Potter, Simon, Lindholt, Jes S, Golledge, Jonathan, Norman, Paul E, van Rij, Andre, Powell, Janet T, Eriksson, Per, Stefansson, Kari, Thompson, John R, Humphries, Steve E, Sayers, Robert D, Deloukas, Panos, Samani, Nilesh J, Bown, Matthew J   +47 more
openaire   +9 more sources

Two novel D151Y and M391T LDLR mutations causing LDLR transport defects in Thai patients with Familial hypercholesterolemia

Clinica Chimica Acta, 2010
Familial hypercholesterolemia (FH) is an autosomal dominant disorder caused by mutations in the low density lipoprotein receptor (LDLR) gene. Two novel LDLR mutations, D151Y and M391T, had been previously identified in unrelated Thai patients with heterozygous FH.
Nutjaree, Jeenduang, Athisake, Ruangpracha, Chamras, Promptmas, Klai-upsorn S, Pongrapeeporn, Sureerut, Porntadavity   +4 more
openaire   +2 more sources

Interactions of NEU1 with ASGR and LDLR

2020
Development of atherosclerosis, the hardening of the arteries, is dependent on levels of serum cholesterol, which is regulated by the liver via LDL receptors (LDLR). The expression and internalization of LDL receptors depend on several proteins including PCSK9.
openaire   +1 more source

Comparative studies of the avian and the mammalian LDLR

2009
The low-density lipoprotein receptor (LDLR) is the key component in the feed-back regulated maintenance of cholesterol homeostasis. Members of the LDLR gene family are involved in lipoprotein transport and in signal transduction pathways. Endocytic members of the LDLR gene family employ adaptor proteins for efficient endocytosis.
openaire   +1 more source

LDLR

1997
A. Neil Barclay, Marion H. Brown, S.K. Alex Law, Andrew J. McKnight, Michael G. Tomlinson, P. Anton van der Merwe   +5 more
openaire   +1 more source

Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling

Protein and Cell, 2021
Wei Yang, Xiaojun Zheng, Zhenhai Zhang   +2 more
exaly  

LDLR

1998
Tak W. Mak, Josef Penninger, John Roder, Janet Rossant, Mary Saunders   +4 more
openaire   +1 more source