Results 141 to 150 of about 3,458,304 (355)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Co‐exposure of cadmium and lead on bone health in a southwestern Chinese population aged 40‐75 years [PDF]

, 2019
Xiaomeng Li, Renjia Li, Jiuming Yan, Yang Song, Jiao Huo, Zhen Lan, Jinyao Chen, Lishi Zhang   +7 more
openalex   +1 more source

Emblica officinalis mitigates intestinal toxicity of mice by modulating gut microbiota in lead exposure

, 2023
Yaping Wang, Hui Zhou, Yanyun Che, Xin Wan, Xiaoxue Ding, Shengnan Zheng, Chenyang Wu, Miao Qin, Yanling Xu, Yi Yu, Muhammad Fakhar‐e‐Alam Kulyar, Kun Li, Yi Wu   +12 more
openalex   +1 more source

DNA Breathing Dynamics in the Presence of a Terahertz Field

, 2009
We consider the influence of a terahertz field on the breathing dynamics of double-stranded DNA. We model the spontaneous formation of spatially localized openings of a damped and driven DNA chain, and find that linear instabilities lead to dynamic ...
A. Usheva, A.R. Bishop, Alexandrov, Alexandrov, Alexandrov, B.S. Alexandrov, Bondar, Brucherseifer, Chu, Chu, Dauxois, Frohlich, George, Ho, Homenko, Ince, K.Ø. Rasmussen, Korenstein-Ilan, Lie George, Markelz, Olshevskaya, Olshevskaya, Peyrard, Samson, Usheva, V. Gelev, Vanossi, Verschaeve, Whittaker   +28 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Chronic exposure to arsenic in drinking water can lead to resistance to antimonial drugs in a mouse model of visceral leishmaniasis [PDF]

, 2013
Meghan Perry, Susan Wyllie, Andrea Raab, Jörg Feldmann, Alan H. Fairlamb   +4 more
openalex   +1 more source

The Immunotoxicity of Chronic Exposure to High Levels of Lead: An Ex Vivo Investigation [PDF]

, 2020
Kawinsaya Pukanha, Supabhorn Yimthiang, Wiyada Kwanhian   +2 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Time to Ban Lead in Industrial Paints and Coatings

Frontiers in Public Health, 2015
Perry eGottesfeld
doaj   +1 more source