Results 131 to 140 of about 384,964 (298)
A Method for Incorporating User Modelling
In this paper a method is presented for adding user modelling to existing software systems. The method consists of seven steps that lead from initial analysis to the definition and evaluation of the elements needed for the adaptive behaviour. Further
van der Weide, Theo +2 more
core
, 2011 Despite the growing evidence of the beneficial nature of customer and user involvement in new product or service development, research into user types and customer characteristics for innovation is still scarce.
Schuurman, Dimitri +2 more
core
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
, 2015 Nopeasti kehittyvä teknologia ja digitalisoituminen vaikuttavat yhä voimakkaammin elämäämme. Eri laitteiden avulla pyrimme pysymään yhteydessä fyysisen maailman rinnalle syntyneeseen digitaaliseen todellisuuteen.
Pekkanen, Siina
core
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
User-Centered Provisioning of Interlibrary Loan: a Framework
, 2018 Interlibrary loan, or ILL, has grown from a niche service for privileged scholars to a ubiquitous service. Yet, workflows still assume specialness. Users’ needs should come first and that means redesigning ILL into a unified linear user-centered process.
Kurt Munson
core
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Fine-grained user models by means of asynchronous web technologies
, 2008 Although asynchronous HTTP technologies have grown in importance with the emergence of Web 2.0, most web-based Adaptive Hypermedia Systems (AHS) still exclusively use server- side monitoring of user behaviour to set up the user model.
Hauger, David
core
Lead User Innovation and the UK Outdoor Trade since 1850 [PDF]
, 2009 This article explores lead user innovation in the UK outdoor trade since 1850. The long term perspective allows an analysis of the changing role and impact of lead user sports people on clothing and equipment for mountaineering and other outdoor ...
Rose, M B, Parsons, M C
core