Results 241 to 250 of about 384,964 (298)

Exploring Self-Management-Based Mobile Health User Typologies and Associations Between User Types and Satisfaction With Key Mobile Health Functions: Comparative Study of Various Fitness and Weight Management App User Types. [PDF]

JMIR Med Inform
Wang T, Fan Y, Li Z, Jiao X, Fang Q, Ma J, Lei J.   +6 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Helix 1.0: An open-source framework for reproducible and interpretable machine learning on tabular scientific data. [PDF]

Patterns (N Y)
Aguilar-Bejarano E, Lea D, Sivakumar K, Mase JM, Omidvar R, Li R, Kettle T, Mitchell-White J, Alexander MR, Winkler DA, Figueredo G.   +10 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Acceptability of Using Large Language Models to Support Smoking Cessation Attempts: a Qualitative Study Among African Americans Who Smoke. [PDF]

Nicotine Tob Res
McKinney W, Fernholz D, Pakhomov S, Kotlyar M, Dufresne S, Thuras P, Welle E, Japuntich S.   +7 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Towards a feature-based regulatory benchmark for user-centred SaMD design in cancer care. [PDF]

BMJ Health Care Inform
Kheirinejad S, Brett CL, Davis RL, Schwartz DL, Shaban-Nejad A.   +4 more
europepmc   +1 more source

Protocol for inferring mechanical stresses in tissues using ForSys, an open-source Python tool. [PDF]

STAR Protoc
Borges A, Miranda-Rodríguez JR, Ceccarelli AS, Ventura G, Sedzinski J, López-Schier H, Chara O.   +6 more
europepmc   +1 more source

Postural Education in School-Aged Populations: Development and Usability Evaluation of a Mobile Biofeedback App (EduBack). [PDF]

JMIR Hum Factors
García-Luna MA, García-Jaén M, Ruiz-Fernández D, Manchado C, Cortell-Tormo JM.   +4 more
europepmc   +1 more source

CurrentView: a tool for visualization and comparison of nanopore ionic current signals. [PDF]

Bioinformatics
Daneshvar Kakhaki P, Ghohabi Esfahani N, Akeson S, Jain M.   +3 more
europepmc   +1 more source