Results 211 to 220 of about 256,086 (255)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Community-informed design of personalized patient-facing materials to facilitate ED-initiated treatment of opioid use disorder. [PDF]

PEC Innov
Nath B, Levy DR, Strycharz H, Sherak RAG, Gilkes J, Oladele C, Sarpong DF, Schoenfeld EM, Hawk K, Panthagani K, Patel P, Hooper CD, D'Onofrio G, Melnick ER.   +13 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

From pen to paper-based screening: an early-stage colorimetric µPAD with desktop-app readout for lead and nitrite. [PDF]

RSC Adv
Basu A, Asani PC, Nath K, Das S.
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

FishFeats: streamlined quantification of multimodal labeling at the single-cell level in 3D tissues. [PDF]

Bioinformatics
Letort G, Foley T, Mignerey I, Bally-Cuif L, Dray N.   +4 more
europepmc   +1 more source

Accessible data collection methods in clinical trials: do current best practices for the implementation of electronic patient-reported outcome measures (ePROMs) meet accessibility standards? [PDF]

J Patient Rep Outcomes
Mowlem FD, O'Donohoe P.
europepmc   +1 more source

A causal AI and explainable optimization framework for social robot design. [PDF]

iScience
Liu Z, Liang X, Yang F.
europepmc   +1 more source

LUMIN: an open source dynamic reconfigurable lightboard for neurorehabilitation and athletic training. [PDF]

HardwareX
Peterson ZD, Stefanovic F.
europepmc   +1 more source

Mapping digital popularity: Analyzing the network attention patterns of national forest parks based on Douyin (Tiktok) data. [PDF]

PLoS One
Zhang S, Gu Q.
europepmc   +1 more source