Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization
Advanced Science, EarlyView.This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin +11 more
wiley +1 more source
The Impact of Resilience and Leader-Member Exchange on Actual Turnover: A Prospective Study of Nurses in Acute Hospitals. [PDF]
Healthcare (Basel)Yamaguchi S +4 more
europepmc +1 more source
A diary study on the moderating role of leader-member exchange on the relationship between job characteristics, job satisfaction, and emotional exhaustion. [PDF]
Front Psychol, 2022 Poetz L, Volmer J.
europepmc +1 more source
Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development
Advanced Science, EarlyView.This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen +11 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang +9 more
wiley +1 more source
How leader-member exchange affects university teachers' scholarship of teaching and learning performance: a comprehensive analysis of psychological capital, LMX differentiation, and traditionality. [PDF]
Front PsycholFang J, Zhang Q, Rao P, Ouyang G.
europepmc +1 more source
When Teamwork Works: Examining the Relationship Between Leader-Member Exchange Differentiation and Team Creativity. [PDF]
Front Psychol, 2021 Du J +4 more
europepmc +1 more source
Advanced Science, EarlyView.Hyperglycemia during pregnancy impairs the fusion of trophoblast cells into syncytiotrophoblasts, leading to fetal growth restriction. This impaired fusion is mediated by Tim1 downregulation via hyperglycemia‐induced ROS. Antioxidant therapy during pregnancy promotes syncytiotrophoblast formation by upregulating Tim1 expression, thus alleviating fetal ...
Junsen She +14 more
wiley +1 more source
Exploring the influence of spiritual leadership, leader - member exchange, and traditionality orientation on employee voice behavior. [PDF]
BMC PsycholYu Y, Pitafi S.
europepmc +1 more source
Role Overload and Work Performance: The Role of Psychological Strain and Leader-Member Exchange. [PDF]
Front Psychol, 2021 Tang WG, Vandenberghe C.
europepmc +1 more source