Results 31 to 40 of about 14,602 (250)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Examination of Leader-Member Exchange and Employee Performance of Nurses

Sağlık ve Hemşirelik Yönetimi Dergisi, 2019
INTRODUCTION: The aim of this study is to examine the perception of nurses regarding leader-member exchange and employee performance and to investigate the impact of the level of leader-member exchange on employee performance.
Özlem Özer
doaj   +1 more source

Leader member exchange in leaders' support for voice

, 2021
While previous research underscores the role of leaders in stimulating employee voice behaviour, comparatively little is known about what affects leaders' support for such constructive but potentially threatening employee behaviours. We introduce leader member exchange quality (LMX) as a central predictor of leaders' support for employees' ideas for ...
Urbach, Tina (Dr.), Fay, Doris (Prof. Dr.)   +1 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Roles of perceived exchange quality and organisational identification in predicting turnover intention

IIMB Management Review, 2012
This paper explores whether the perceived quality of the leader–member exchange and the general environment of exchange could predict turnover intention.
Manish Kumar, Shailendra Singh
doaj   +1 more source

Trust and Leader—Member Exchange [PDF]

Journal of Leadership & Organizational Studies, 2008
Trust in work relationships is an intriguing topic in leader—member exchange (LMX) research, however, previous LMX studies examined trust as unidimensional. Research on LMX has yet to explore the multidimensional nature of trust and how different dimensions may affect LMX quality.
Terri A. Scandura, Ekin K. Pellegrini
openaire   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The Mediating Role of Trust in Manager in The Effect of Leader-Member Exchange on Job Satisfaction in Nursing

Sağlık ve Hemşirelik Yönetimi Dergisi
Aim: The aim of the study is to determine the mediating role of trust in manager in the effect of leader-member exchange on job satisfaction of nurses working in a university hospital.
Nazlıhan Efe Sayan, Aysun Türe
doaj   +1 more source