Results 51 to 60 of about 20,488 (297)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Leader member exchange dan keterikatan kerja pegawai honorer
, 2022 This study aims to determine the relationship between Leader Member Exchange (LMX) and work engagement on honorary employees. This research is a correlational quantitative research. The subjects in this study were 148 temporary employees.
Prasetyo, Yanto +3 more
core +1 more source
Spanning leader–subordinate relationships through negative interactions : An examination of leader–member exchange breaches [PDF]
, 2020 The study aims to discover the dynamic and processual nature of a supervisory relationship (here a leader–member exchange) through a novel, theoretical concept termed leader–member exchange breach, and by examining the characteristics of negative ...
Kangas, Hilpi
core +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Humanitas: Indonesian Psychological Journal, 2018 This research background was the low indicator of employee well-being (EWB) in Jakarta that derived from several employee surveys. One factor that has significant influence to EWB is management leadership.
Nuri Sadida, Nurindah Fitria
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Exchange Relationships and Helping Behavior: An Empirical Analysis of Data from CGSS2015
Psychology Research and Behavior Management, 2022 Junwei Zheng,1 Yu Gu,1 Yan Wang,2 Hongtao Xie3 1Faculty of Civil Engineering and Mechanics, Kunming University of Science and Technology, Kunming, People’s Republic of China; 2Collaborative Innovation Center for Integration of Terrestrial & Marine ...
Zheng J, Gu Y, Wang Y, Xie H
doaj
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Organizational Support and Leader Member Exchange as Perceived by Staff Nurses [PDF]
Egyptian Journal of Health Care, 2019 Background: Supporting employees in health care sectors playes an important role as employees are the backbone of the hospital .This support from organization or supervisor will help achieving both organizational and employees goals.
Fawzia mohammed Badran +2 more
doaj +1 more source