Results 151 to 160 of about 5,869,436 (291)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Managing trust problems in multidisciplinary primary health care collaborations

International Journal of Integrated Care, 2014
Iris de Putter, Sanneke Schepman, Ronald Batenburg   +2 more
doaj   +3 more sources

Superior outcomes with offspring B-leader-matched haploidentical versus older matched sibling donors in AL/MDS patients aged ≥40 years. [PDF]

Front Immunol
Wei Y, Tang J, Yang R, Shao Y, Luan S, Wang L, Wang L, Li F, Wu Y, Qian K, Peng B, Zhang H, Ge D, Fang Y, Huang L, Liu Q, Dou L, Liu D.   +17 more
europepmc   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Τοπική ανάπτυξη και πρωτοβουλία Leader: γεωγραφική ανάλυση επενδύσεων στην Ελλάδα

, 2015
Η παρούσα διπλωματική εργασία έχει ως στόχο την ανάλυση των αποτελεσμάτων της εφαρμογής του προγράμματος Leader στον αγροτικό χώρο των διαφόρων περιφερειών της Ελλάδας.
Αλατζάς, Ευάγγελος - Παναγιώτης
core  

How Medicaid Accountable Care Organizations Advance Maternal Health Care Quality: Drivers of Change and Challenges From the Perspective of ACO Leaders, Clinicians, and Care Coordinators. [PDF]

Milbank Q
Ogden SN, Loo S, Cole MB, Thompson KD, Lim KN, Gordon SH, Ncube CN, Patton EW, Lasser KE, McCloskey L.   +9 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Multimodal artificial intelligence assessment of simulated cardiac arrest performance: a pilot study. [PDF]

Resusc Plus
Dion PM, Cardenas-Mancera J, Touchie C, LeBlanc V, Mbadjeu A, Nickel C, Waldolf R, Yoo Y, Bergamascki L, Sekhavati P, Crooks S, Gu Y.   +11 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

How leaders make decisions about implementing health interventions in the Veterans Health Administration. [PDF]

Health Care Manage Rev
Painter JT, Pyne JM, Curran GM, Woodward EN.   +3 more
europepmc   +1 more source