Results 161 to 170 of about 5,869,436 (291)

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Co-Creation and Usability Testing of a Digital Cardiac Rehabilitation Program (eCardiacRehab): Design and Development Study. [PDF]

JMIR Cardio
Nordfonn OK, Johnsen Ramstad K, Roed Pettersen T, Hjertvikrem N, Aamot Aksetøy IL, Agcaoili Borge AJ, Gerdts E, Hesthammer JG, Hole T, Instenes I, Isaksen A, Krumsvik OA, Landaas M, Moltu C, Rotevatn S, Schjøtt J, Sommersten CH, Tryti JO, Norekvål TM.   +18 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Challenges and Opportunities of Human Immunodeficiency Virus, Hepatitis B Virus and Hepatitis C Virus Control and Elimination Policies, Regulations, and Strategies in Ethiopia. [PDF]

Health Sci Rep
Dagnaw M, Geremew BM, Gezie LD.
europepmc   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Narrative Construction of Leader Identity in a Leader Development Program Context

, 2009
With the increasing globalization, new organizational structures, and rapid change the leader has been increasingly individualized and personalized. The leader has been put under pressure to reveal a leadership, in which the personality of the individual leader is increasingly important.
openaire   +3 more sources

A Community Hospital Implementation of a Mobile Preoperative Peripheral Nerve Block Service in Non-OR Environments for Hip Fracture Patients. [PDF]

A A Pract
Versloot J, Feng S, Hoondert S, Araujo T, Kure K, Faldas LG, Lax I, Terpou BA, Seuren L, Conway K, Livshits O, Lau A.   +11 more
europepmc   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Facilitating leaders to create workplaces where healthcare staff want to work: evaluating a leadership development program. [PDF]

Front Health Serv
Cardiff S, Frost DM.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source