Results 121 to 130 of about 3,322,209 (361)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Chief Justice Leadership: A Brief Sketch of Its Landscape, Structure, and Operation [PDF]

open access: yes, 2019
This article examines chief justice leadership of the United States Supreme Court during the judicial decision-making process and develops a model of such leadership in three distinct parts: landscape, structure, and operation.
Root, David A.
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Contextualizing the challenges of education graduate students in the Philippines: translating needs analysis into strategic solutions

open access: yesDiscover Education
The Philippine government has described the state of the education system, including graduate education, as both "miseducation" and a "failed system," resulting in poor quality.
Nilo Jayoma Castulo   +6 more
doaj   +1 more source

Third culture young women: Understanding their life experiences and leadership perspectives : A thesis presented in partial fulfilment of the requirement for the degree of Master of Business Studies (Management) at Massey University, New Zealand [PDF]

open access: yes, 2016
Globalisation influences how leadership is understood and practiced and impacts on culturally diverse interactions in New Zealand communities. Examining leadership and intersecting diversity with regards to culture, gender and age could provide a ...
Chatiya Nantham, Rhema Roja
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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