Results 131 to 140 of about 1,204,692 (299)

Australian Rural Leadership Foundation 2022 Impact Report

open access: yes, 2022
The Australian Rural Leadership Foundation (ARLF) was established 30 years ago to serve rural, regional and remote Australia through leadership development.
Woolcock, Geoffrey, Renando, Chad
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Sustainability of Tourism as Development Strategy for Cultural-Landscapes in China: Case study of Ping'an Village

open access: yesJournal of Rural and Community Development, 2015
This case study explores the challenges associated with tourism development in a village within China's Longji Rice Terrace Scenic Area. We employ Butler's (1980) Tourism Area Life Cycle model as a starting point for understanding the evolution
Courtney Kimmel   +4 more
doaj  

Through Their Own Words: Towards a New Understanding of Leadership Through Metaphors [PDF]

open access: yes, 2003
This paper suggests that metaphors are essential to understanding leadership. Metaphors can serve as underlying, organizing structures of leadership thinking and experience, and they can be mobilized in order to accomplish interpersonal goals.
Mayer-Schonberger, Viktor   +1 more
core  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Changes in university students after joining a service leadership program in China

open access: yes, 2016
This study examined the effectiveness of a 4.5-day service leadership program for students from Chinese universities using objective outcome evaluation.
Shek, DTL, Lin, L
core  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

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