Results 91 to 100 of about 484,060 (292)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Leadership styles of senior executives in business and government organizations: A comparative study

South African Journal of Business Management, 1988
This article has two main objectives. First, to analyse to what extent organizational differences affect the basic relationship between style of leadership and power and information.
G. Chitayat, I. Venezia
doaj   +1 more source

Perceptions of Transactional and Transformational Leaders According to Gender

, 2018
The lack of females occupying leadership positions in the modern workplace has prompted the research of this study. In order to better understand the perceptions that exist regarding successful leadership, this study was conducted with the intention of ...
Garstka, Andrew N., Harris, Lindsay D., Igram, Quinn I.   +2 more
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The Effect of Leadership Style on Midwives’ Performance, Southwest, Ethiopia

Journal of Healthcare Leadership, 2023
Belete Fenta Kebede,1 Tsigereda Aboye,2 Yalemtsehay Dagnaw Genie,3 Tsegaw Biyazin Tesfa,1 Aynalem Yetwale Hiwot1 1School of Midwifery, Jimma University, Jimma, Ethiopia; 2Department of Management, Jimma University, Jimma, Ethiopia; 3Department of Nursing,
Fenta Kebede B, Aboye T, Dagnaw Genie Y, Tesfa TB, Yetwale Hiwot A   +4 more
doaj  

Employability of women managers in the education sector: A study on their leadership role [PDF]

The teaching profession both in this country and internationally is, with few exceptions, predominated by women as it has traditionally been seen as a ‘suitable’ job for women. However, a look at the statistics reveals that despite the large numbers of
Amaratunga, Dilanthi, Haigh, Richard, Shanmugam, M.   +2 more
core  

Pengaruh Gaya Kepemimpinan Terhadap Kinerja Pegawai Pada Badan Perencanaan, Penelitian Dan Pembangunan Daerah (Bappeda) Kabupaten Morowali Dengan Motivasi Kerja Sebagai Variabel Intervening [PDF]

, 2016
The aims of this research are: 1) to test and analyze the influence of leadership style on work motivation in BAPPEDA of Morowali Regency; 2) to test and analyze direct influence of leadership styles on civil servants' performance; 3) to test and analyze
Pratama, T. (Tulus)
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source