Results 51 to 60 of about 28,839 (303)

Solid-State Transformers for Interfacing Solar Panels to the Power Grid: An Optimum Design Methodology of a High Frequency Transformer for dc-dc Converter Applications [PDF]

open access: yes, 2016
Nowadays the use of power electronic interfaces to integrate distributed generation with the power grid is becoming relevant due to the increased penetration of renewable energy sources like solar, and the continued ...
George, Kenny
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

A novel dual-stator hybrid excited synchronous wind generator [PDF]

open access: yes, 2009
This paper presents a novel dual-stator hybrid excited synchronous wind generator and describes its structural features and operation principle. The no-load magnetic fields with different field currents are computed by 3-D finite-element method.
Chengfeng, Y.   +5 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

open access: yesFEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz   +9 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

Analytical Selection of Leakage Inductance for Single-Phase Dual Active Bridge Converters

open access: yesApplied Sciences
The single-phase dual active bridge (DAB) DC/DC converter is a vital component in modern power electronics systems, facilitating efficient bidirectional power transfer between various energy sources and loads. One of the critical aspects in the design of
Hamid Naseem, Jul-Ki Seok
doaj   +1 more source

Mathematical model analysis of new-type magnetic integrated CRT considering magnetic leakage

open access: yesJournal of Measurement Science and Instrumentation, 2022
A novel magnetic integrated controllable reactor of transformer type (CRT) has the advantages of simple structure, flexible assembly, convenient maintenance and practicability.
WANG Tiange   +2 more
doaj  

Investigation of the End Leakage Flux in Fractional Slot Concentrated-Winding Surface Permanent Magnet Machines

open access: yesIEEE Access, 2019
When the end leakage flux or end leakage inductance cannot be ignored in a permanent magnet (PM) machine (e.g., a PM machine with a short axial length), the analysis of the machine is a time-consuming three-dimensional (3-D) issue.
Xianbao Chen   +4 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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