Results 61 to 70 of about 3,883 (286)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Analytical Modeling of Slot Leakage Inductance for Hairpin Windings

Machines
With the increasing demand for higher efficiency and power density, innovative winding techniques have become crucial in modern electric machines. Hairpin windings are increasingly used in electric machines, particularly in high-current applications.
Hasnain Nisar, Ali M. Bazzi
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Analytical Selection of Leakage Inductance for Single-Phase Dual Active Bridge Converters

Applied Sciences
The single-phase dual active bridge (DAB) DC/DC converter is a vital component in modern power electronics systems, facilitating efficient bidirectional power transfer between various energy sources and loads. One of the critical aspects in the design of
Hamid Naseem, Jul-Ki Seok
doaj   +1 more source

Mathematical model analysis of new-type magnetic integrated CRT considering magnetic leakage

Journal of Measurement Science and Instrumentation, 2022
A novel magnetic integrated controllable reactor of transformer type (CRT) has the advantages of simple structure, flexible assembly, convenient maintenance and practicability.
WANG Tiange, TIAN Mingxing, ZHANG Huiying   +2 more
doaj  

Investigation of the End Leakage Flux in Fractional Slot Concentrated-Winding Surface Permanent Magnet Machines

IEEE Access, 2019
When the end leakage flux or end leakage inductance cannot be ignored in a permanent magnet (PM) machine (e.g., a PM machine with a short axial length), the analysis of the machine is a time-consuming three-dimensional (3-D) issue.
Xianbao Chen, Hongyu Shu, Yitong Song, Shuang Luo, Cheng Guo   +4 more
doaj   +1 more source

Leakage inductance of a prototyped single tooth wound synchronous reluctance motor [PDF]

, 2017
This paper explores the inductance characteristics present in single tooth wound synchronous reluctance motors, specifically the stator leakage inductance.
Barrie Mecrow, Mecrow, B.C., James Widmer, Donaghy-Spargo, C.M., Widmer, J.D., Christopher Donaghy-Spargo   +5 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Analytical Transformer Leakage Inductance Modelling

, 2023
Photovoltaics, railway systems, cancer treatment, and particle accelerators are only a few examples of applications that include a power electronic converter. Many of these converter topologies are galvanically isolated, i.e. they contain a transformer as key element. The transformer leakage inductance significantly affects the converter's operation as
openaire   +3 more sources

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source