Results 41 to 50 of about 398 (215)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Resonant Excitation Analysis on Asymmetrical Lateral Leakage of Light in Finite Zero-Contrast Grating Mirror

open access: yesIEEE Photonics Journal, 2020
Resonant excitation analysis on asymmetrical lateral leakage of light in the finite zero-contrast grating (ZCG) mirror is demonstrated, and the size effect of the excited source is investigated.
Tian Sang   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Advances in the research of seismic-wave leaky modes

open access: yes地球与行星物理论评
When seismic waves propagate in layered structures, dispersion phenomena occur. Based on the characteristics of dispersion curves, underground velocity structures can be estimated.
Caiwang Shi, Zhengbo Li, Xiaofei Chen
doaj   +1 more source

Optical Absorption Characteristic in Thin a-Si Film Embedded Between an Ultrathin Metal Grating and a Metal Reflector

open access: yesIEEE Photonics Journal, 2013
We numerically investigated the effect of an optically ultrathin top metal grating in an absorber structure composed of an amorphous silicon (a-Si) thin film and a metal reflector for efficient solar cells.
Sangjun Lee, Sangin Kim
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Bend-resistant leaky multi-trench fiber with large mode area and single-mode operation. [PDF]

open access: yesPLoS ONE, 2018
A novel structure of modified multi-trench fiber (MTF) with characteristics of bend-resistance and large mode-area is proposed. In this structure, each low refractive-index trench of traditional MTF is broken by two gaps up and down.
Shaoshuo Ma   +6 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Analysis of Leaky Modes in Photonic Crystal Fibers Using the Surface Integral Equation Method

open access: yesCrystals, 2018
A fully vectorial algorithm based on the surface integral equation method for the modelling of leaky modes in photonic crystal fibers (PCFs) by solely solving the complex propagation constants of characteristic equations is presented.
Jung-Sheng Chiang
doaj   +1 more source

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