Results 51 to 60 of about 8,118 (290)

A Direct Near-Field Observation of Conversion Between Waveguide Modes and Leaky Modes in Periodic Metal Structures

IEEE Access, 2023
In order to directly observe the conversion between guided-wave modes and leaky-wave modes in a periodic structure, quadrilateral periodic metal diaphragms arranged in two ways on metal surfaces were analyzed.
Chia Ho Wu, Zhenyu Qian, Wei Wang, Jianqi Shen, Xianqing Lin, Li-Yi Zheng, Fang He, Xiaolong Wang, Zhuoyuan Wang, Song Tsuen Peng, Guobing Zhou, Linfang Shen, Yun You, Hang Zhang   +13 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Fast Leaky Modes on Cylindrical Metal-Ceramic Interfaces

, 1990
In our previous work [1,2,3,], we have studied in detail the radial-axial modes in an infinitely clad isotropic rod. We have shown that in metal matrix composites, where the fibers are stiffer than the matrix, many of these modes are leaky, transmitting ...
Wadley, H., H. N. G. Wadley, E. Drescher-Krasicka, J. A. Simmons, Drescher-Krasicka, E., Simmons, J.   +5 more
core   +2 more sources

Bound states in the continuum (BIC) accompanied by avoided crossings in leaky-mode photonic lattices

Nanophotonics, 2020
When two nonorthogonal resonances are coupled to the same radiation channel, avoided crossing arises and a bound state in the continuum (BIC) appears with appropriate conditions in parametric space. This paper presents numerical and analytical results on
Lee Sun-Goo, Kim Seong-Han, Kee Chul-Sik
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Leaky Surface Plasmon Polariton Modes at an Interface Between Metal and Uniaxially Anisotropic Materials

IEEE Photonics Journal, 2013
By solving analytically derived characteristic equations, leaky surface waves are found to exist at an interface between a metal material and a uniaxially anisotropic dielectric material with its optic axis falling in the plane of the interface. Both the
Hsuan-Hao Liu, Hung-chun Chang
doaj   +1 more source

Seeing is believing

Light: Science & Applications, 2022
Bound states in the continuum are realized in many optical systems as “dark states”, and their presence can be detected in the regime of leaky modes via resonances in far-fields.
Sergey Krasikov, Yuri Kivshar
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source