Results 51 to 60 of about 1,054,457 (281)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Maximized vertical photoluminescence from optical material with losses employing resonant excitation and extraction of photonic crystal modes

Nanophotonics, 2019
Optical losses of a host material together with the total internal reflection phenomenon can significantly reduce photoluminescence external quantum efficiency of embedded light-emitters. This is not only the case for light-emitting color centers in thin
Fait Jan, Varga Marián, Hruška Karel, Remeš Zdeněk, Jurka Vlastimil, Kromka Alexander, Rezek Bohuslav, Ondič Lukáš   +7 more
doaj   +1 more source

A Direct Near-Field Observation of Conversion Between Waveguide Modes and Leaky Modes in Periodic Metal Structures

IEEE Access, 2023
In order to directly observe the conversion between guided-wave modes and leaky-wave modes in a periodic structure, quadrilateral periodic metal diaphragms arranged in two ways on metal surfaces were analyzed.
Chia Ho Wu, Zhenyu Qian, Wei Wang, Jianqi Shen, Xianqing Lin, Li-Yi Zheng, Fang He, Xiaolong Wang, Zhuoyuan Wang, Song Tsuen Peng, Guobing Zhou, Linfang Shen, Yun You, Hang Zhang   +13 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Leaky modes in low-damping ε-near-zero slabs [PDF]

, 2013
We present a complex-mode analysis of an ε-near-zero metamaterial slab made of chains of core-shell nanocylinders. The mesoscopic nature of the slab induces narrowband, strong, effective nonlocal response mediated by leaky modes.
De Ceglia D., Campione S., Scalora M., Vincenti M. A., Capolino F.   +4 more
core   +2 more sources

Bound states in the continuum (BIC) accompanied by avoided crossings in leaky-mode photonic lattices

Nanophotonics, 2020
When two nonorthogonal resonances are coupled to the same radiation channel, avoided crossing arises and a bound state in the continuum (BIC) appears with appropriate conditions in parametric space. This paper presents numerical and analytical results on
Lee Sun-Goo, Kim Seong-Han, Kee Chul-Sik
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source