Results 61 to 70 of about 8,118 (290)

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Graphene Enhanced Leaky Mode Resonance in Tilted Fiber Bragg Grating: A New Opportunity for Highly Sensitive Fiber Optic Sensor

open access: yesIEEE Access, 2019
Tilted fiber Bragg grating (TFBG) presents many unique spectral characteristics for sensing. The widespread approaches to date are based on the cut-off mode resonance and surface plasmon resonance (SPR), whereas the leaky mode resonance is ignored in the
Zhihong Li   +4 more
doaj   +1 more source

Monolayer molecular sensing using infrared leaky waveguide mode

open access: yesAIP Advances, 2021
Surface-enhanced infrared absorption spectroscopy is attractive for molecular sensing due to its access to chemical bonds with high detection sensitivity.
Tieyan Zhang   +6 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket   +14 more
wiley   +1 more source

Band dynamics of leaky-mode photonic lattices

open access: yesOptics Express, 2019
External waves incident on a periodic metamaterial lattice couple to it at frequencies corresponding to the leaky, or second, stop band. The resulting leaky-mode or guided-mode resonance effects are useful in device design and spectral manipulation. Indeed, some of the most important properties of metamaterials are associated with the leaky stopband ...
Sun-Goo, Lee, Robert, Magnusson
openaire   +2 more sources

Static Structures in Leaky Mode Waveguides [PDF]

open access: yesApplied Sciences, 2019
In this work, we suggest a new method of expanding the field of view in bottom-exit, leaky mode devices for transparent, monolithic, holographic, near-eye display. In this approach, we propose the use of static, laser-induced, grating structures within the device substrate to break the leaky mode light into diffracted orders.
Daniel Pettingill   +2 more
openaire   +2 more sources

Anti‐CD19 CAR T Cells in Autoimmune Encephalitis: Inflammation Controlled, Neurodegeneration Unchecked?

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos   +9 more
wiley   +1 more source

Analysis of guided and leaky modes of planar optical waveguides using transparent boundary conditions

open access: yesAPL Photonics
We present a numerical approach to compute and characterize both guided and leaky modes in a multilayer planar optical waveguide made of any lossy and dispersive materials.
Xiaorun Zang, Andriy Shevchenko
doaj   +1 more source

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