Results 91 to 100 of about 221,276 (349)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

MODELING AND SIMULATION OF A LEAN SYSTEM. CASE STUDY OF A PAINT LINE IN A FURNITURE COMPANY [PDF]

open access: yes
Since they were first developed, lean methodologies have grown in importance and scope and have been applied in both manufacturing and service. However, determining how to transform a common manufacturing company into a lean one, as well as how to ...
Ki-Chan NAM   +2 more
core  

The Integration of a Lean Manufacturing Competency-based Training Course into University Curriculum [PDF]

open access: yes, 2010
The manufacturing industry has become extremely competitive in nature and each company’s survival depends on gaining an edge in their respective field. Lean manufacturing has emerged as the leading management philosophy in this struggle.
Cooper, John J., Jr.
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

LEAN ACCOUNTING: SUATU ALTERNATIF TEKNIK AKUNTANSI MANAJEMEN DALAM INDUSTRI MANUFAKTUR

open access: yesJurnal Ilmiah Akuntansi dan Bisnis, 2010
Manufacturing techniques have been developed to embrace theaims of continuous improvement. Continuous improvement would leadcompanies to win business competition. One technique that gains moreand more followers is lean manufacturing.
Eka Ardhani Sisdyani
doaj  

Applications of lean thinking: a briefing document [PDF]

open access: yes, 2007
This report has been put together by the Health and Care Infrastructure Research and Innovation Centre (HaCIRIC) at the University of Salford for the Department of Health.
Kagioglou, M, Sapountzis, S
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Relationship between lean manufacturing tools and their sustainable economic benefits. [PDF]

open access: yesInt J Adv Manuf Technol, 2022
Díaz-Reza JR   +4 more
europepmc   +1 more source

Enabling initiation of a lean management system in SMEs: a case study of a high performance plastics manufacturer [PDF]

open access: yes, 2013
This paper investigates the challenges in developing a Lean Management System in a typical Small to Medium Size Enterprise (SME’s) in the UK. Through a series of pilot projects measured and implemented by action research this case study reflects on the ...
Jalali-Roudsari, Mehdi, Murray, Susan
core  

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