Results 61 to 70 of about 9,002 (304)

The cultural evolution of human communication systems in different sized populations: usability trumps learnability. [PDF]

PLoS ONE, 2013
This study examines the intergenerational transfer of human communication systems. It tests if human communication systems evolve to be easy to learn or easy to use (or both), and how population size affects learnability and usability.
Nicolas Fay, T Mark Ellison
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Learnability of Description Logics

, 1992
This paper considers the learnability of subsets of first-order logic. Prior work has established two boundaries of learnability: Haussler [ 1989 ] has shown that conjunctions in first-order logic cannot be learned in the Valiant model, even if the form ...
William W. Cohen, Haym Hirsh
core   +1 more source

Mapping and Analysis of Open Source Software (OSS) Usability for Sustainable OSS Product

IEEE Access, 2019
The increase in the number of open source software (OSS) users have drawn attention to improving usability. Usability is a clear concept that encompassing both task and user characteristics as well as functionality.
Kareem Abbas Dawood, Khaironi Yatim Sharif, A. A. Zaidan, Abdul Azim Abd Ghani, Hazura Binti Zulzalil, B. B. Zaidan   +5 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Methodological Problems and Strategic Goals of the Work on Creation of the Theory and Technology of New Generation Intelligent Computer Systems

Цифровая трансформация
The main methodological problems and strategic goals of work on creating the theory and technology of intelligent computer systems of a new generation are considered.
V. V. Golenkov, N. A. Guliakina, D. V. Shunkevich   +2 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Phonotactic constraints and learnability: analyzing Dagaare vowel harmony with tier-based strictly local (TSL) grammar

Open Linguistics
This paper examines vowel harmony in Dagaare using the Tier-Based Strictly Local (TSL) framework, focusing on tongue root, rounding, backness, and height harmonies.
Angsongna Alexander
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Learnability Project Research Team [PDF]

, 2015
Learnability Project Research TeamNational Institutes of Health DC00433, RR7031KK, DC00076, DC001694 (PI ...
Gierut, Judith A.
core   +1 more source