Results 51 to 60 of about 8,409,785 (376)

The Sex Inclusive Research Framework to address sex bias in preclinical research proposals

Nature Communications
An interactive Sex Inclusive Research Framework (SIRF) supports the evaluation of in vivo and ex vivo research proposals to address the risk of sex bias in preclinical research.
Natasha A. Karp, Manuel Berdoy, Kelly Gray, Lilian Hunt, Maggy Jennings, Angela Kerton, Matt Leach, Jordi L. Tremoleda, Jon Gledhill, Esther J. Pearl, Nathalie Percie du Sert, Benjamin Phillips, Penny S. Reynolds, Kathy Ryder, S. Clare Stanford, Sara Wells, Lucy Whitfield   +16 more
doaj   +1 more source

The learning curve of laparoscopic rectal cancer surgery of millennial surgeons: Lessons for a safe implementation in low- and middle-income countries

Journal of Minimal Access Surgery, 2023
Objective: This study aimed to analyse the learning curve (LC) in laparoscopic rectal cancer resections of 2 millennial surgeons during the implementation of the first laparoscopic rectal cancer surgery programme in low- and middle-income country (LMIC ...
Hamza Sekkat, Amine Souadka, Leila Alaoui, Ali Rafik, Zakaria Belkhadir, Laila Amrani, Amine Benkabbou, Raouf Mohsine, Anass Mohammed Majbar   +8 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Learning curve for Lichtenstein hernioplasty

Open Access Surgery, 2010
Mark Wiese1, Thomas Kaufmann2, Jürg Metzger3, Guido Schüpfer4, Philipp Honigmann11Surgical Department, 2Quality and Risk Management, 3Visceral Surgery, 4Anaesthesiological Department, Cantonal Hospital Lucerne, Lucerne ...
Mark Wiese, Thomas Kaufmann, Jürg Metzger, et al   +3 more
doaj  

Endoscopic sleeve gastroplasty: the learning curve

Endoscopy International Open, 2017
Background and study aims Endoscopic sleeve gastroplasty (ESG) is gaining traction as a minimally invasive bariatric treatment. Concern that the learning curve may be slow, even among those proficient in endoscopic suturing, is a barrier to widespread ...
Christine Hill, Mohamad El Zein, Abhishek Agnihotri, Margo Dunlap, Angela Chang, Alison Agrawal, Sindhu Barola, Saowanee Ngamruengphong, Yen-I Chen, Anthony N. Kalloo, Mouen A. Khashab, Vivek Kumbhari   +11 more
doaj   +1 more source

Reconciling modern machine learning practice and the bias-variance trade-off

, 2019
Breakthroughs in machine learning are rapidly changing science and society, yet our fundamental understanding of this technology has lagged far behind.
Belkin, Mikhail, Hsu, Daniel, Ma, Siyuan, Mandal, Soumik   +3 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

The dynamics of syntax acquisition: facilitation between syntactic structures [PDF]

, 2011
This paper sets out to show how facilitation between different clause structures operates over time in syntax acquisition. The phenomenon of facilitation within given structures has been widely documented, yet inter-structure facilitation has rarely been
Ben-Horin, Berman, Berman, Giora, Givón, Glinert, Greene, Homa, MICHAEL KEREN, Ninio, Nosofsky, Ravid, Ryan, TAMAR KEREN-PORTNOY, Ziv, Ziv   +15 more
core   +1 more source

Learning curve and postoperative outcomes of minimally invasive esophagectomy.

Journal of Thoracic Disease, 2019
Surgical innovation is necessary to increase surgical effectiveness and to decrease postoperative complications, but can be associated with learning curves.
L. Claassen, F. van Workum, C. Rosman
semanticscholar   +1 more source