Results 111 to 120 of about 634,587 (308)

Friendship or Facilitation: People with Learning Disabilities and Their Paid Carers [PDF]

This article compares the composition and characteristics of the social networks of 14 people with learning disabilities with those of 24 of their paid support staff.
Rebecca Pockney
core  

Homefield College of Further Education Inspection of FEFC-funded provision in non-sector establishments for students with learning difficulties and/or disabilities (Report from the Inspectorate, 2000-01) [PDF]

, 2001
Independent Establishment 08/00 Inspection of FEFC-Funded provision in the non-sector establishment for students with learning difficulties and/or disabilities.

core  

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

The Interact: Centre Inspection of FEFC-funded provision in non-sector establishments for students with learning difficulties and/or disabilities (Report from the Inspectorate, 1999-00) [PDF]

, 2000
Independent Establishment 11/2000 Inspection of FEFC-Funded provision in the non-sector establishment for students with learning difficulties and/or disabilities.

core  

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

Insights from Eye Blinks into the Cognitive Processes Involved in Visual Word Recognition

Journal of Cognition
Behavioral differences in speed and accuracy between reading familiar and unfamiliar words are well-established in the empirical literature. However, these standard measures of skill proficiency are limited in their ability to capture the moment-to ...
Ronen Hershman, David L. Share, Elisabeth M. Weiss, Avishai Henik, Adi Shechter   +4 more
doaj   +1 more source

Queen Elizabeth's Foundation Brain Injury Centre Inspection of FEFC-funded provision in non-sector establishments for students with learning difficulties and/or disabilities (Report from the Inspectorate; 2000-01) [PDF]

, 2000
Independent Establishment 04/00 Inspection of FEFC-Funded Provision in non-sector establishments for students with learning difficulties and/or disabilities.

core  

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Metacognitive Monitoring in Reading Comprehension: Examining the Role of Cognitive Flexibility, Vocabulary, and Fluency in Young Readers

Journal of Intelligence
This study examined associations between vocabulary knowledge, reading fluency, cognitive flexibility, and metacognitive monitoring accuracy in reading comprehension among fifth-grade students.
Vered Markovich, Shoshi Dorfberger, Vered Halamish, Tami Katzir, Dana Tal, Rotem Yinon   +5 more
doaj   +1 more source

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source