Results 121 to 130 of about 6,561,272 (426)

Neuronal C/EBPβ Shortens the Lifespan via Inactivating NAMPT

Advanced Science, EarlyView.
Schematic diagram illustrating the mechanism of shortened lifespan in Thy 1‐C/EBPβ transgenic mice and intervention strategies. Briefly, C/EBPβ/AEP escalation in the aging brain triggers NAMPT fragmentation and NAD+ depletion. Knockout of AEP from Thy 1‐C/EBPβ Tg/Tg mice ameliorates cognitive impairments and elongates the lifespan.
Bowei Li, Zhongyun Xie, Mengmeng Wang, Shuke Nie, Zhengjiang Qian, Xin Meng, Xia Liu, Seong Su Kang, Keqiang Ye   +8 more
wiley   +1 more source

Supporting Families through Early Intervention

Iranian Rehabilitation Journal, 2003
Internationally early intervention programmes for infants and preschoolers with disabilities have proved to be remarkably successful. In many countries, they began with teachers for visually impaired or hearing impaired children visiting the family home ...
Roy McConkey
doaj  

Rights and responsibilities: Fair treatment for adults with learning disabilities [PDF]

, 2008
This leaflet discusses fair treatment for adults with learning disabilities. It set out to see if the Disability Discrimination Act (1995) had helped service providers to treat people with learning disabilities ...
Lerpiniere, Jennifer, Stalker, Kirsten
core  

Unraveling Neurodevelopment: Synergistic Effects of Intrinsic Genetic Programs and Extrinsic Environmental Cues

Advanced Science, EarlyView.
Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang, Shukui Zhang, Huiyang Jia, Fen Ji, Jianwei Jiao   +4 more
wiley   +1 more source

Classification of Functioning, Disability, and Health for Children and Youth: ICF-CY Self Care (SCADI Dataset) Using Predictive Analytics [PDF]

arXiv, 2018
The International Classification of Functioning, Disability, and Health for Children and Youth (ICF-CY) is a scaffold for designating and systematizing data on functioning and disability. It offers a standard semantic and a theoretical foundation for the demarcation and extent of wellbeing and infirmity.
arxiv  

Learning Evaluation of the Disability Rights Fund [PDF]

, 2015
The Disability Rights Fund (DRF) is a partnership between funders and the disability community that provides grants and other support for work at country-level towards the realisation of rights affirmed in the Convention on the Rights of Persons with ...
Charles Lusthaus, Elisabetta Micaro, Futsum Abbay, Sandra Nduwimfura   +3 more
core  

Does attending a charter school Reduce the likelihood of being placed into special education? Evidence from Denver, Colorado [PDF]

, 2017
We use administrative data to measure whether attending a charter school in Denver, Colorado, reduces the likelihood that students are newly classified as having a disability in primary grades.
Carpenter, Dick M., Clayton, Grant, Winters, Marcus A.   +2 more
core   +1 more source

PLXDC1+ Tumor‐Associated Pancreatic Stellate Cells Promote Desmoplastic and Immunosuppressive Niche in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
This study uncovers the activation, heterogeneity, and regulatory roles of pancreatic stellate cells (PSCs) at single‐cell and spatial levels. It further identifies PLXDC1+ PSCs near aggressive LRRC15+ cancer‐associated myofibroblasts and SPP1+ macrophages, forming a desmoplastic and immunosuppressive tumor niche that promotes CD8+ T cell exhaustion ...
Yanhua Du, Yizhou Zhao, Judong Li, Jiaxin Wang, Shenglan You, Yao Zhang, Li Zhang, Jihong Yang, Hamid Alinejad‐Rokny, Shujie Cheng, Chenghao Shao, Duowu Zou, Youqiong Ye   +12 more
wiley   +1 more source

Mortality in people with learning disability: risks, causes, and death certification findings in London.

Developmental Medicine & Child Neurology, 2008
Two thousand people with learning disabilities registered as service users in two London districts were followed up for 8 years to ascertain, in those who died, age and cause of death and significant associations with early death. Respiratory disease was
S. Hollins, M. Attard, N. V. Fraunhofer, S. Mcguigan, P. Sedgwick   +4 more
semanticscholar   +1 more source

The changing of the guard: groupwork with people who have intellectual disabilities [PDF]

, 2009
This paper considers the impact of service systems on group activities. It describes an inter-professional groupwork project facilitated by a social worker and a community nurse.
A. McClimens, A. Mullender, B. Nirje, B.W. Tuckman, C. Barnes, C.J.G. Gersick, D. Cardore, D. Herd, D. Ward, D.G. Race, F. Kevan, H. Northen, J. Edge, J. Walmsley, J. Walmsley, K. Nichols, L. Staples, M. Cohen, M. Doel, M. Preston-Shoot, P. Reason, P. Trevithick, P. Williams, R. Burke, R. Smith, R. Townsley, R.J. Stancliffe, S-J. Hays, S. Read, S. Russell, S.H. Chia, T. MacKay, T. Tyson, W. Utting   +33 more
core   +1 more source