Results 81 to 90 of about 244,151 (263)

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Universities as Learning Organizations in a Cross-cultural Perspective

Управленческое консультирование, 2018
Objective: The paper attempts to link the concepts of Learning Organizations and Organizations culture with Universities within a cross-cutural perspective.
Jerome Dumetz
doaj  

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Changing Classroom Ecology to Support Continued Engineering Enrollment

Trends in Higher Education
Engineering requires more bachelor’s degree graduates to meet the growing demand for engineering skills globally. One way to address this demand is increasing student degree completion, which is lower than higher education in general.
Matthew Bahnson, Eric T. McChesney, Linda DeAngelo, Allison Godwin   +3 more
doaj   +1 more source

Prominent Movement Disorders in RNU2‐2‐Related Spliceosomopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Pediatric movement disorders often overlap with neurodevelopmental diseases, suggesting shared molecular mechanisms. Variants in small nuclear RNA (snRNA) genes encoding spliceosome components have recently been associated with neurodevelopmental disorders, termed “RNUopathies.” We analyzed genome sequencing data from 14 patients with ...
Magdalena Krygier, Ugo Sorrentino, Matias Wagner, Marta Zawadzka, Anna Lemska, Maria Mazurkiewicz‐Bełdzińska, Michael Zech   +6 more
wiley   +1 more source

Forecasting political voting: A high dimensional machine learning approach

Machine Learning with Applications
We present a novel machine learning approach to predict voting patterns in Brazil’s Chamber of Deputies. Using a high-dimensional dataset and a time-series methodology, our models aim to accurately forecast legislative decisions.
Pedro Caiua Campelo Albuquerque, Daniel Oliveira Cajueiro   +1 more
doaj   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Adapting improvement science tools and routines to build racial equity in out-of-school time STEM spaces

Frontiers in Education
Over the past two decades, networked improvement communities (NICs) have become popular for their collaborative, evidence-based approaches to enduring educational challenges.
Jennifer Iriti, Lori Delale-O'Connor, Jennifer Zoltners Sherer, Talia Stol, Disan Davis, Chris Matthis, Danielle Lowry, Alison Slinskey Legg   +7 more
doaj   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Do gifted children without specific learning disabilities read more efficiently than typically developing children?

Frontiers in Psychology
IntroductionThere are no published data on the written language skills of gifted children (GC). The objective of the present study was to evaluate reading abilities of GC vs. normative data from typically developing French children (TDC).
Laurent Lesecq, Laurent Lesecq, Laurent Querne, Laurent Querne, Julie Gornes, Laura Buffo, Louise Corbel, Anne Gaelle Le Moing, Anne Gaelle Le Moing, Patrick Berquin, Patrick Berquin, Béatrice Bourdin   +11 more
doaj   +1 more source