Results 61 to 70 of about 244,151 (263)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Learning Organization

, 2020
Learning organization is a type of organization that focuses on creating, acquiring, and transferring knowledge. Employees in such organizations are encouraged to generate new knowledge and actively exchange new learning across departments. Learning organizations are built around the notion of generative learning, which emphasizes continuous ...
Paroutis, Sotirios, Sammut-Bonnici, Tanya, McGee, John, Cooper, Cary L.   +3 more
openaire   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Inclusive Leadership and Intent to Stay in a Midwestern US Nonprofit Faith-Based Hospital – A Cross-Sectional Study of Nursing Staff

Journal of Healthcare Leadership
R Wesley Swen,1,2 David W Brown,1 Mary Luallen1 1Peabody College, Vanderbilt University, Nashville, TN, USA; 2School of Allied Health Professions, Loma Linda University, Loma Linda, CA, USACorrespondence: R Wesley Swen, Loma Linda University School of ...
Swen RW, Brown DW, Luallen M
doaj  

Learning organizations in Saudi universities: Implications for occupational therapy education. [PDF]

J Taibah Univ Med Sci, 2023
Al-Heizan MO.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Adoption of Artificial Intelligence in Organizational Coaching Processes

AI
Artificial intelligence (AI) is transforming how organizations develop human potential, offering scalable and data-driven support for coaching and capability building.
Yanis Faquir, Arnaldo Santos, Henrique S. Mamede   +2 more
doaj   +1 more source

Role of adaptive leadership in learning organizations to boost organizational innovations with change self-efficacy. [PDF]

Curr Psychol, 2023
Chughtai MS, Syed F, Syed F, Naseer S, Chinchilla N.   +4 more
europepmc   +1 more source