Results 51 to 60 of about 244,151 (263)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Conceptualization and scale development for big data-based learning organization capability

Frontiers in Big Data
IntroductionIn today's competitive business landscape, organizations must enhance learning and adaptability to gain a strategic edge. While big data significantly influences organizational learning, a comprehensive tool to measure this capability has ...
Nesrin Alkan, Deniz Ersan Yilmaz, Bilal Baris Alkan   +2 more
doaj   +1 more source

Entrepreneurial leadership, learning organization and organizational culture relationship: a systematic literature review

Journal of Innovation and Entrepreneurship, 2023
The purpose of this study is to examine the relations between organizational culture, learning organizations, and entrepreneurial leadership. The study concentrated on how organizational culture, learning organizations, and entrepreneurial leadership are
Robson Mekonnin Shiferaw, Zerihun Ayenew Birbirsa, Shimels Zewdie Werke   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Strategic Leadership and Systems Connection as Key Predictors of Learning Organization Outcomes: Evidence from Saudi Arabian Nursing Education

Education Sciences
The current research examined how nursing schools in Saudi Arabia operate as learning organizations (LOs). The Dimensions of Learning Organization Questionnaire (DLOQ) was administered to 208 participants to measure and examine the seven LO dimensions ...
Nojoud Abdullah Alrashidi, Grace Ann Lim Lagura, Ma Christina Bello Celdran   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A Choir as a Learning Organization

Social Sciences, 2011
The article analyses a choir as a learning organization and reveals the advantage of a choir – an art organization as a learning organization related to its capability to learn faster than other organizations. Learning of a choir as learning of an organization is analysed on three levels; peculiarities of a choir as a learning organization based on ...
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Mixed Methods Findings of a Psychological First Aid Digital Peer Learning Program for Child-Supporting Professionals

International Journal of First Aid Education
Background: The need to provide children affected by the armed conflict between Russia and Ukraine with mental health and psychosocial support (MHPSS) services outweighs available support.
Charlotte Njua Mbuh, Ian Jones, Ian Steed, Karen E. Watkins, Kari Eller, Malika Dhakwa, Panu Saaristo, Reda Sadki, Séverine Jacomy-Vité, Victoria Marsick, Yuliia Yushchenko   +10 more
doaj   +2 more sources