Results 71 to 80 of about 398,042 (310)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Harnessing Transfer Learning for Alzheimer\u27s Disease Prediction
, 2023 Nowadays, Alzheimer\u27s Disease (AD) has become a massive problem for middle-aged and older adults. Although due to its long incubation period and early mild symptoms, patients have a more extended period and more possibilities to check out, it is still
Ihnaini, Baha +2 more
core +1 more source
Studies in Learning and Teaching, 2023 The goal of education and training is the transfer of learning which requires translating theories to knowledge, skills and learned behaviour. Education can only achieve its intended purpose when theories taught in the classroom are connected to ...
John Olayemi Okunlola
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Students’ perception of learning transfer: Which EAP skills transfer best?
International Journal of English for Academic PurposesEnglish for academic purposes (EAP) courses improve English academic skills, build learner confidence, and prepare students for future academic success (Zou & Jiang, 2021). To be successful post-EAP, these skills must transfer to other learning contexts (
Julie McCarroll +2 more
doaj +1 more source
Revisiting Use of Real-Time Polling for Learning Transfer
Journal of Teaching and Learning with Technology, 2015 Instructors in five different undergraduate courses designed their courses to include real-time polling to increase their students’ levels of engagement and participation in an attempt to enhance students’ learning transfer.
Sheri Stover +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Integrated Leadership Development Programmes: Are they Effective and What Role Does Coaching Play? [PDF]
International Journal of Evidence Based Coaching and Mentoring, 2013 Integrated Leadership Development Programmes (IDLPs) have become increasingly popular in recent years. These programmes combine different elements such as 360° feedback, experiential learning, group coaching, executive coaching and action learning, over ...
David Coates
doaj
Sports Teaching, Traditional Games, and Understanding in Physical Education: A Tale of Two Stories
Frontiers in Psychology, 2020 Unlike Dickens’s novel, this is not a tale of light and darkness, order and chaos, good and evil…It is, though, a story worth to be told about two standpoints about games and sports, teaching and research, physical education simply put, that have pursued
Raúl Martínez-Santos +3 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source