Results 71 to 80 of about 4,861,455 (309)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Regularized Least Square Regression with Unbounded and Dependent Sampling
Abstract and Applied Analysis, 2013 This paper mainly focuses on the least square regression problem for the -mixing and -mixing processes. The standard bound assumption for output data is abandoned and the learning algorithm is implemented with samples drawn from dependent sampling ...
Xiaorong Chu, Hongwei Sun
doaj +1 more source
Result of two-stage least square method.
, 2022 Result of two-stage least square method.
Haitao Wu (2411155) +2 more
core +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
, 2016 Least-square mean and standard error of semen quality traits of different INCENP haplotype combinations in Chinese Holstein bulls.
Qiang Jiang (764314) +9 more
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
PREDIKSI WAKTU KETAHANAN HIDUP DENGAN METODE PARTIAL LEAST SQUARE
E-Jurnal Matematika, 2013 Coronary heart disease is caused due to an accumulation of fat on the inside walls of blood vessels of the heart (coronary arteries). The factors that had led to the occurrence of coronary heart disease is dominated by unhealthy lifestyle of patients ...
PANDE PUTU BUDI KUSUMA +1 more
doaj +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Least Square Approach to Out-of-Sample Extensions of Diffusion Maps
Frontiers in Applied Mathematics and Statistics, 2019 Let X = X ∪ Z be a data set in ℝD, where X is the training set and Z the testing one. Assume that a kernel method produces a dimensionality reduction (DR) mapping 𝔉: X → ℝd (d ≪ D) that maps the high-dimensional data X to its row-dimensional ...
Jianzhong Wang
doaj +1 more source
Balanced clustering with least square regression
, 2017 Clustering is a fundamental research topic in data mining. A balanced clustering result is often required in a variety of applications. Many existing clustering algorithms have good clustering performances, yet fail in producing balanced clusters.
Nie, Feiping (feipingnie@gmail.com) +8 more
core +1 more source