Results 61 to 70 of about 444,182 (307)
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
The Use of Partial Least Squares Method To Remove Multicollinearity [PDF]
المجلة العراقية للعلوم الاحصائية, 2010 In this research the estimation of the regression parameters was clarified using least squares and partial least squares compared with the normal method in terms of its ability to be free from the problem of Multicollinearity between the predictive ...
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Least squares fitting the three-parameter inverse Weibull density [PDF]
, 2010 The inverse Weibull model was developed by Erto [10]. In practice, the unknown parameters of the appropriate inverse Weibull density are not known and must be estimated from a random sample.
Marušić, Miljenko +5 more
core +1 more source
High performance technique FIR Filter Using Least Squares Method
Journal of Engineering and Sustainable Development, 2008 The FIR filter is the one from the most DSP components used. There are two main approaches to design of FIR, first using the windows that have simple mathematics calculations but its results are not optimal.
Wisam Haitham Abbood
doaj
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Partial Least Squares Methods for Non-Metric Data [PDF]
, 2009 Partial Least Squares (PLS) methods embrace a suite of data analysis techniques based on algorithms belonging to PLS family. These algorithms consist in various extensions of the Nonlinear estimation by Iterative PArtial Least Squares (NIPALS) algorithm,
Russolillo, Giorgio
core
Optimization Method of Fusing Model Tree into Partial Least Squares
ITM Web of Conferences, 2017 Partial Least Square (PLS) can’t adapt to the characteristics of the data of many fields due to its own features multiple independent variables, multi-dependent variables and non-linear.
Yu Fang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source