Results 71 to 80 of about 444,182 (307)

On the equivalence between Total Least Squares and Maximum Likelihood PCA [PDF]

, 2005
The maximum likelihood PCA (MLPCA) method has been devised in chemometrics as a generalization of the well-known PCA method in order to derive consistent estimators in the presence of errors with known error distribution.
Wentzell, P., Van Huffel, S., Peter D. Wentzell B, Schuermans, M., I. Markovsky A, M. Schuermans A, Markovsky, I., S. Van Huffel A   +7 more
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Online correction method for AD conversion based on least squares algorithm

Dianzi Jishu Yingyong, 2020
Aiming at the nonlinear problem between the actual physical values and the converted digital values in AD conversion process, a software online correction method is proposed.
Jia Hongmin, Zhang Liguang, Dan Jianchao
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A robust partial least squares method with applications [PDF]

, 2007
Partial least squares regression (PLS) is a linear regression technique developed to relate many regressors to one or several response variables. Robust methods are introduced to reduce or remove the effect of outlying data points.
Romera, Rosario, González, Javier, Peña, Daniel   +2 more
core  

APPROXIMATED AREA CALCULATION BY USING DISCRETE LEAST SQUARES METHOD

Malaysia Journal of Invention and Innovation
This research delves into the application of the discrete least squares method for approximating the area of Pulau Ketam, an island located in Selangor, Malaysia.
Sidik Rathi, Nurzalina Harun, Ain Nur Dania Hassin, Zubaidah Sadikin, Mohd Agos Salim Nasir   +4 more
doaj   +2 more sources

The Least Squares Stochastic Finite Element Method in Structural Stability Analysis of Steel Skeletal Structures

International Journal of Applied Mechanics and Engineering, 2015
The main purpose of this work is to verify the influence of the weighting procedure in the Least Squares Method on the probabilistic moments resulting from the stability analysis of steel skeletal structures.
M. Kamiński, J. Szafran
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Assessment of longitudinal modulus of elasticity in structural elements of Pinus Caribaea timber beams

Vértices, 2012
The current standard NBR 7190/1997 (Project of Timber Structures) makes no reference to tests for determining the stiffness and strength in parts of structural lumber; restricting the analysis to bodies-of-tests with small dimensions and without defects.
André Luis Christoforo, Fábio de Paiva Cota, Túlio Hallak Panzera, Claudenir Facincani Franco, Vitor Correa de Mattos Barreto   +4 more
doaj   +1 more source

Efficient Parameters Estimation Method for the Separable Nonlinear Least Squares Problem

Complexity, 2020
In this work, we combine the special structure of the separable nonlinear least squares problem with a variable projection algorithm based on singular value decomposition to separate linear and nonlinear parameters. Then, we propose finding the nonlinear
Ke Wang, Guolin Liu, Qiuxiang Tao, Min Zhai   +3 more
doaj   +1 more source