Results 81 to 90 of about 3,586,130 (307)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Swedish parental leave and gender equality - Achievements and reform challenges in a European perspective [PDF]

Sweden was the first country to introduce paid parental leave also to fathers in 1974, and this legislation has since then continuously been reformed in order to bring about a more equal parenthood.
Duvander, Ann-Zofie, Ferrarini, Tommy, Thalberg, Sara   +2 more
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Will The Real Family-Friendly Employer Please Stand Up: Who Permits Parents To Reduce Working Hours For Purposes of Childcare? [PDF]

Balancing work and family life can be a challenge, especially when a person needs to adjust her work schedule to deal with a family crisis. If the crisis involves a long term problem, such as caring for a sick or injured child that requires several ...
Patrick Nolen, Robert Hutchens
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Impact of psychosocial work factors on risk of medically certified sick leave due to common mental disorders: a nationwide prospective cohort study of Norwegian home care workers

BMC Public Health
Background The Norwegian home care services experience a high level of sick leave, a large proportion of which is due to common mental disorders. A substantial number of such cases can be attributed to psychosocial factors at work, but more knowledge ...
Rigmor Harang Knutsen, Morten Birkeland Nielsen, Lars-Kristian Lunde, Øivind Skare, Håkon A. Johannessen   +4 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Educational Leave of Absence: Retaining High-Potential Employees Pursuing MBA Degrees [PDF]

, 2012
[Excerpt] Surveys show that 78% of companies include tuition reimbursement as a part of their benefits offerings compared to 0% who offer to pay-off existing student loans. These statistics alone shed light on why a growing number of workers are deciding
Edwards, Sarah, Meyers, Ashley
core   +1 more source

The meaning of work from the perspective of women after maternity leave

, 2022
La presente investigación trata sobre las experiencias y desafíos de las madres en la reincorporación al trabajo después de la licencia por maternidad. Por lo tanto, el objetivo fue analizar las experiencias después del regreso de la licencia de maternidad entre los trabajadores de una fábrica de cerveza en la región noreste de Brasil.
Torres, Ana Carolyne Abreu Fontinelle, Fontenele, Rafael Mondego, Santos, Simone Silvana Saraiva, Silva, Ellen Mariany Lima, Almeida, Ana Caroline Vieira, Sousa, Antonia Jaqueline da Silva, Cunha, Sabrina Sousa Pereira, Almeida, Hariane Freitas Rocha   +7 more
openaire   +1 more source