Results 141 to 150 of about 352,824 (358)

Proteomic and Ubiquitinated Proteome Insights Into ER Stress Responses in Chinese Hamster Ovary Cells Under Mild Hypothermic Conditions

Biotechnology and Bioengineering, EarlyView.
Proteomic analysis of CHO cells under mild hypothermia (31°C) reveals ER stress responses, ubiquitination dynamics, and adaptive mechanisms. Magnetic immuno‐affinity enrichment and mass spectrometry highlight protein regulation differences in non‐producer versus producer cells, offering insights for optimising biopharmaceutical production of IgG1 and ...
David Ryan, Christiana‐Kondylo Sideri, Michael Henry, Selvaprakash Karuppuchamy, Esen Efeoglu, Paula Meleady   +5 more
wiley   +1 more source

Harnessing chimeric antigen receptor macrophages against solid tumors

Cancer Communications, EarlyView.
Abstract Macrophages are prevalent in multiple tumors and exhibit diverse and potent functional activities. Therapeutic reprogramming of macrophage phenotypes represents a promising strategy for cancer immunotherapy. Engineering chimeric antigen receptors (CARs) to endow macrophages with anti‐tumor capacities demonstrated encouraging efficacy ...
Mengru Wang, Zhen Qin, Xiu‐Wu Bian, Yu Shi   +3 more
wiley   +1 more source

Production of lectin-affinity matrices for process-scale glycoprotein purification [PDF]

, 2011
A selection of prokaryotic lectins with a variety of glycan specificities and affinities have been identified, cloned, expressed in Eschericia coli and characterised.
Clarke, Paul A., Keogh, Damien, O'Connell, Michael, O'Connor, Brendan, Thompson, Roisin   +4 more
core  

CD24 is a promising immunotherapeutic target for enhancing efficacy of third‐generation EGFR‐TKIs on EGFR‐mutated lung cancer

Cancer Communications, EarlyView.
Abstract Background Third‐generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) show initial efficacy in EGFR‐mutated lung cancer, but residual disease persists. This study aimed to investigate cluster of differentiation 24 (CD24) as a translational immunotherapeutic target for enhancing third‐generation EGFR‐TKI efficacy.
Jiaqi Liang, Guoshu Bi, Xiaolong Huang, Zhijie Xu, Yiwei Huang, Yunyi Bian, Guangyao Shan, Wei Guo, Yuanliang Yan, Qihai Sui, Xiaodong Yang, Zhencong Chen, Tao Lu, Huan Zhang, Qun Wang, Wei Jiang, Cheng Zhan   +16 more
wiley   +1 more source

A homing receptor-IgG chimera as a probe for adhesive ligands of lymph node high endothelial venules. [PDF]

, 1990
The binding of lymphocytes to high endothelial venules (HEV) within peripheral lymph nodes (pln) is thought to be mediated by a lectinlike adhesion molecule termed the pln homing receptor (pln HR). The cloning and sequencing of cDNAs encoding both murine
Fennie, C, Geoffroy, JS, Imai, Y, Lasky, LA, Rosen, SD, Watson, SR   +5 more
core  

Biotechnological Potential of Seaweeds from Bahia, Brazil: Metabolomic insights, Photoprotection and Antioxidant Activity

Chemistry &Biodiversity, EarlyView.
Chemical profile, photoprotective, and antioxidant potential of Padina sp., Caulerpa sertularioides, and Solieria filiformis collected in Bahia, Brazil. ABSTRACT Seaweeds have wide biotechnological applications. This study evaluated the chemical profile, photoprotective, and antioxidant potential of Padina sp., Caulerpa sertularioides, and Solieria ...
Keila Almeida Santana, Isadora de Jesus da Silva, Victor Pena Ribeiro, José Marcos de Castro Nunes, Hosana Maria Debonsi, Ian Castro‐Gamboa, Lorena Rigo Gaspar, Gustavo Souza dos Santos, Aníbal de Freitas Santos Júnior   +8 more
wiley   +1 more source

C‐6‐Modified 2‐F‐Fucose Derivatives as Inhibitors of Fucosyltransferases

ChemBioChem, EarlyView.
A series of C6‐modified guanosine‐diphosphate‐2‐F‐fucose analogs and corresponding prodrugs are designed, synthesized, and biologically evaluated as inhibitors of cellular fucosylation. Certain analogs potently inhibit fucosyltransferases (FUT) FUT1, 3, 6, and 9 while showing minimal activity for FUT8, highlighting the potential for selective FUT ...
Yanyan Liu, Geert‐Jan Boons
wiley   +1 more source

Fluorescence Studies of Saccharide Binding to Wheat‐Germ Agglutinin (Lectin) [PDF]

, 1974
Jean‐Paul Privat, Franck Delmotte, Gérard MIALONIER, Philippe Bouchard, Michel Monsigny   +4 more
openalex   +1 more source

Effect of Genotype on the Properties of Flours and Protein Isolates Derived From Wrinkled and Round Peas

Cereal Chemistry, EarlyView.
ABSTRACT Background and Objectives This study evaluated the effect of seed shape on the composition, functional, and quality properties of pea flours and protein isolates. Wrinkled‐seed (WPAs) and round‐seed (RPA) pea accessions were selected from a genome‐wide association study panel.
Cassia Galves, Krishna Kishore Gali, Thomas D. Warkentin, James House, Michael Nickerson   +4 more
wiley   +1 more source

A method for the direct demonstration of the lectin-binding components of the human erythrocyte membrane [PDF]

, 1976
Minna Tanner, David J. Anstee
openalex   +1 more source