Results 281 to 290 of about 229,497 (351)

Label‐Free and Microplate‐Based Dissection of Glycan‐Virus Interactions Using Polymer‐Tethered Glyconanoparticles

Small Methods, EarlyView.
This work demonstrates the use of polymer‐tethered glycosylated gold nanoparticles for the label‐free evaluation of influenza virus binding in a simple microplate. Sialylated linear and branched glycans are integrated using a modular capture and assembly process. The microplate‐based assays are shown to correlate with biolayer interferometry and can be
Sarah‐Jane Richards, Simona Chessa, Lloyd Sayer, Irina Ivanova, Sanaz Ahmadipour, Alexander N. Baker, Marc Walker, Simone Dedola, Katherine A. Scott, Oliver Dibben, Robert A. Field, Matthew I. Gibson   +11 more
wiley   +1 more source

Nanomedicine for Oral Delivery: Strategies to Overcome the Biological Barriers

Small Methods, EarlyView.
Oral delivery is a preferred administration route for many clinical applications, valued for its strong patient compliance. In this review, how nanoparticles are engineered and deployed to overcome the gastrointestinal barriers that impede clinical translation of oral delivery formulations is examined.
Luke J. Kubiatowicz, Nima Pourafzal, Audrey T. Zhu, Zhongyuan Guo, Ronnie H. Fang, Liangfang Zhang   +5 more
wiley   +1 more source

Synthesis of Boronic Acid‐Functionalized Core–Shell Mesoporous Silica–TiO2 Nanocomposite for Specific Enrichment of Glycopeptides From Biological Samples

Small Methods, EarlyView.
The schematic illustrates a workflow showing the current investigation using a boronic acid‐functionalized core–shell mesoporous silica‐TiO₂ (CSMS@TiO₂‐GLYMO‐APB) for N‐glycopeptide enrichment from biological samples, involving trypsin digestion, enrichment, deglycosylation with PNGase F, and subsequent mass spectrometry (MALDI‐TOF MS and Nano‐LC‐MS/MS)
Mohamed Adly Gab‐Allah, Maryam Adelipour, Hyojin Hwang, Reham M. Marzouk, Heejin Lim, Jooyeon Oh, Ji‐Hyun Cha, Jaebeom Lee, Jeongkwon Kim   +8 more
wiley   +1 more source

Cascade Ultrasonic Cavitation Enables Microbubble–Nanoparticle Hybrid to Broadly Accumulate and Penetrate into Pancreatic Ductal Adenocarcinoma

Small Structures, EarlyView.
A novel cascade twice ultrasonic cavitation strategy utilizing macrophage membrane‐modified microbubble‐nanoparticle hybrid (MMB@TFHPD) is engineered to enhance drug delivery efficiency in pancreatic ductal adenocarcinoma. The system implements sequential ultrasound applications: initially disrupting the blood–tumor barrier, followed by triggering deep
Dequan Ye, Guowei Wang, Xiao Liu, Yijie Chen, Jifan Chen, Hua Yin, Yuhan Fu, Fei Gao, Lina Tang, Pintong Huang   +9 more
wiley   +1 more source

Cadmium‐Induced Mitochondrial and MAMs Dysregulation in Rat Testis: The Protective Role of D‐Aspartate

Environmental Toxicology, EarlyView.
ABSTRACT Cadmium (Cd), a heavy metal, disrupts the structure of seminiferous tubules and induces cell death at multiple stages of sperm development. Cd also impairs Leydig cells (LCs), resulting in reduced serum testosterone (T) levels. This study primarily examined the impact of Cd on the mitochondrial compartment and mitochondrial‐associated ...
Debora Latino, Sara Falvo, Massimo Venditti, Alessandra Santillo, Giulia Grillo, Gabriella Chieffi Baccari, Imed Messaoudi, Maria Maddalena Di Fiore   +7 more
wiley   +1 more source

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Lectin microarrays: concept, principle and applications

Chemical Society Reviews, 2013
The lectin microarray is a novel platform for glycan analysis, having emerged only in recent years. Unlike other conventional methods, e.g., liquid chromatography and mass spectrometry, it enables rapid and high-sensitivity profiling of complex glycan ...
Jun Hirabayashi, Atsushi Kuno, Hiroaki Tateno   +2 more
exaly   +2 more sources

Evolution of the lectin–complement pathway and its role in innate immunity

Nature Reviews Immunology, 2002
T. Fujita
exaly   +2 more sources

Lectins

Current Opinion in Structural Biology, 1999
Lectins - carbohydrate-binding proteins involved in a variety of recognition processes - exhibit considerable structural diversity. Three new lectin folds and further elaborations of known folds have been described recently. Large variability in quaternary association resulting from small alterations in essentially the same tertiary structure is a ...
Vijayan, M, Chandra, Nagasuma
openaire   +2 more sources

Nucleocytoplasmic lectins

Biochimica et Biophysica Acta (BBA) - General Subjects, 2004
This review summarizes studies on lectins that have been documented to be in the cytoplasm and nucleus of cells. Of these intracellular lectins, the most extensively studied are members of the galectin family. Galectin-1 and galectin-3 have been identified as pre-mRNA splicing factors in the nucleus, in conjunction with their interacting ligand, Gemin4.
John L, Wang, Richard M, Gray, Kevin C, Haudek, Ronald J, Patterson   +3 more
openaire   +2 more sources

Cold Lectins

Vox Sanguinis, 1963
SummaryPlant agglutinins are described which act more strongly as temperature is decreased. Crotalaria mucronata as well as variants of Phaseolus lunatus contain pronounced cold agglutinins against B cells while their action on A1‐cells is not enhanced with decreasing temperature.
F, OTTENSOOSER, M, SATO
openaire   +2 more sources